Off-Line Testing

However, the main reason for the lack of wide application of on-line adaptive control is the lack of economic incentive. On-line identification is rarely required because it is usually possible to predict with off-line tests how the controller must be retuned as conditions vary. The dynamics of the process are determined at different operating conditions, and appropriate controller settings are determined for all the different conditions. Then, when the process moves from one operating region to another, the controller settings are automatically changed. This is called openloop-adaptive control or atn scheduling. 

Are off-line test or bureau systems used as a source of spares ... 

Because the HITRAP facility will not be able to continuously obtain the ESR beam for testing the Cooler trap and the experimental setups, it was decided to install an electron beam ion source (EBIS), which was available from the University of Frankfurt, on the platform for off-line tests. This source (MAXEBIS) is currently being tested and will be used to tune the low-energy beam line (LEBT) towards the Cooler trap, and for tests of the Cooler trap itself. Afterwards, the components will be moved to the HITRAP facility. A more complete overview of the time planning for the construction of the HITRAP facility is presented in Table 7.2. 

In addition to being numericeilly the most important error, misses are usually the most expensive in consequences because they imply feiilure of the system in use. Ftilse eileums, while still costly, can often be reevaluated by slower, off-line testing and usually corrected. 

Always verify the miscibility of the individual solvents in an off-line (test tube) experiment, especially when using buffers, salts, or other solid additives. 

Between 1975 and 1986, six terrestrial nuclear power tests that lasted from 3,000 up to 14,000 h confirmed the rated performances. On the basis of these tests and on a series of off-line tests of TFEs, the system predicted lifetime was not less than 3 years. 

Redundant I/O and application software with alternate online operation and off-line testing. 

Emulation. Allows off-line testing of applications before downloading... 

Before any physical movement is done in the real inspection environment, the optimal robot configuration and motion are planned and simulated in a virtual iuspection environment in the ROBCAD 3D robot simulation system. If any collisions or near-collisions are occurring or all the calculated inspection points can not be reached the robot configuration and/or robot inspection programs can be adjusted off-line accordingly without the need of the physical robot or inspection environment. This ensures that the time scheduled for the physical inspection is used actively for inspection instead of testing and configuration. 

The virtual transducer can be placed in a specific location on the test object surface, it can be moved along a path (e.g. a robot scanning path generated off-line or a path resulting from a real inspection sequence) or it can be moved along the surface, dynamically updating the ultrasonic sound propagation in the material. 

Inappropriate Select compatible materials of construction for materials of con- the specific process struction lead to, Change process parameters (e.g., different acid, corrosion and reduce temperature). Evaluate changes with test potential failure. coupons off-line Dillon 1992... 

Methods developed for on-line technological control have to be tested for the variation of the product composition due to process variations. However, if rugged analytical procedures are developed these multidimensional methods may only require minimal attention during on-line operation. Multidimensional chromatography for the analysis of complex polymer and industrial samples offers chromatogra-phers high productivity and efficiency and is an excellent alternative to off-line methods. 

With a host computer framework, the control package is all in the software. Changing the program can still be agonizing, but the program can be tested off-line. There is more flexibility in the computer system, which can be used for many other purposes, including on-line heat and weight balances. 

Conventionally, the technique has been used off-line, to provide information on the structural integrity of equipment, typically during a pressure test. However, the technique can be used on line by periodically raising the pressure some 5-10% above the maximum operating pressure and one system... 

In the off-line mode of use of the drug file the data-base, stored In a time-shared computer. Is Interrogated through a remote device such as a cathode ray terminal The questions that may be asked Include all the affects of a drug, all the drugs that affect a test, or more specifically does a particular drug affect a particular test procedure by a particular mechanism ... 

The simplest method of coupling enzymatic reactions to electrochemical detection is to monitor an off-line reaction using FIAEC or LCEC. The enzymatic reaction is carried out in a test tube under controlled conditions with aliquots being taken at timed intervals. These aliquots are then analyzed for the electroactive product and the enzyme activity in the sample calculated from the generated kinetic information. 

In the last several years, on-line extraction systems have become a popular way to deal with the analysis of large numbers of water samples. Vacuum manifolds and computerized SPE stations were all considered to be off-line systems, i.e., the tubes had to be placed in the system rack and the sample eluate collected in a test-tube or other appropriate vessel. Then, the eluted sample had to be collected and the extract concentrated and eventually transferred to an autosampler vial for instrumental analyses. Robotics systems were designed to aid in these steps of sample preparation, but some manual sample manipulation was still required. Operation and programming of the robotic system could be cumbersome and time consuming when changing methods. 

Applications Ideally, multiply hyphenated systems should be assembled rapidly in response to real need. Access to these means is restricted to a few laboratories only. Multiple LC hyphenations have been used to analyse test mixtures of polymer additives see Table 7.74. The relative ease with which SEC-UV using CDCI3 as a solvent can be coupled to on-line 1II NMR and an in series off-line FUR (Scheme 7.12b), has been shown for a mixture of polymer additives (BHT, Irganox 1076, DIOP) [666]. Figure 7.35 shows representative spectra for on-flow NMR and MS and off-line FTIR of 2,6-di-f-butyl-4-methoxyphenol. 

Sometimes it is not possible to use even a semicontinuous onstream analyzer, and a sample must be analyzed in a laboratory. For example, the blow-molding characteristics of a plastic must be tested off-line. This often requires that the product be temporarily stored until the laboratory results are obtained. 

The most common (off-line) sample preparation procedures after protein precipitation are solid phase extraction and liquid-liquid extraction. Multiple vendors and available chemistries utilize 96-well plates for solid phase extraction systems and liquid-liquid extraction procedures. Both extraction process can prepare samples for HPLC/MS/MS assay. Jemal et al.110 compared liquid-liquid extraction in a 96-well plate to semi-automated solid phase extraction in a 96-well plate for a carboxylic acid containing analyte in a human plasma matrix and reported that both clean-up procedures worked well. Yang et al.111 112 described two validated methods for compounds in plasma using semi-automated 96-well plate solid phase extraction procedures. Zimmer et al.113 compared solid phase extraction and liquid-liquid extraction to a turbulent flow chromatography clean-up for two test compounds in plasma all three clean-up approaches led to HPLC/MS/MS assays that met GLP requirements. 

Off-line measurements differ significantly from on-line techniques. Offline measurements include safety testing in a laboratory, which has the major advantage of providing available time to redesign the process and/or equipment if a risk is identified. Of course, immediate process response is not possible. 

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