Microsporum

Microsporida Microsporosis Microsporumaudouim Microsporum cams Microstmcture Microstmctures Microtex fibers Microtome knives Micro tunneling Microutility systems Microvilli Microvit... 

Griseofulvin. Although this antibiotic was first isolated ia 1939 and was described as a metabohte of Penicilliumgmeofulvum (20), its action against Microsporum and Trichophyton was only discovered ia 1958. Several modes of action were suggested for (+) 7... 

Indications are mycoses of the skin, hair, and nails due to species of Trichophyton Tpidermophyton floccosum and Microsporum. Yeasts and bacteria are not sensitive. Griseofulvin has a very weak effect against Side effects may include headaches and gastrointestinal disorders, but they are usually only... 

Ketoconazole is active against dermatophytes (Microsporum, Trichophyton Tpidermophyton) yeasts Candida species, Cyptococcus) and the dimorphous... 

Fungal skin infections are primarily caused by dermatophytes such as Trichophyton, Microsporum, and Epidermophyton. Trichophyton rubrum accounts for more than 75% of all cases in the United States.36 To a lesser extent, Candida and other fungal species cause skin infections. With tinea infections, the causative dermatophyte typically invades the stratum corneum without penetration into the living tissues, leading to a localized infection. 

Plant pathogenic fungi -Fusarium pallidoroseum Marine fungi - Microsporum cf. gypseum... 

Superflcial mycoses are usually clinically evident (some will fluoresce when using a Wood s lamp) and can be confirmed by microscopy (using KOH solution) and culture of hairs, nails or scrapings from the edge of skin lesions. Species of Microsporum, Trichophyton, Epidermophyton (all moulds), and of Malassezia, Candida, Pityrospo-rum (all yeasts) cause most superflcial infections. Subcutaneous mycoses are caused by Sporothrix... 

Antifungal activity. Hot water extract of the dried leaf, in hroth culture, was inactive on Epidermophyton floccosum, Microsporum canis, Trichophyton mentagrophytes var. algondonosa, and Trichophyton mentagro ... 

It is obtained from Streptomyces noursei. It has similar antifungal action as amphotericin but is highly toxic and used topically only. It is effective against Candida, Histoplasma, Trichophyton, Blastomyces, Microsporum audouini etc. It is indicated in Candida albicans especially oral moniliasis. 

It is isolated from Penkillium griseofulvium. It is active against Epidermophyton, Trichophyton and Microsporum causing superficial infection or dermatophytosis. 

It has broad spectrum antifungal and antibacterial activity and is effective against Cryptococcus, Blastomyces, dermatophytes, Microsporum, Coccidioides and Candida. Used topically as ointment, lotion, gel, ear drop and vaginal gel. Adverse effects include fever, chills, allergic reaction and even anaphylaxis. 

The topical imidazoles, which currently include clotrimazole, econazole, ketoconazole, miconazole, oxiconazole, sulconazole, and sertaconazole, have a wide range of activity against dermatophytes (epidermophyton, microsporum, and trichophyton) and yeasts, including Candida albicans and Pityrosporum orbiculare (see Chapter 48). 

Tolnaftate is a synthetic antifungal compound that is effective topically against dermatophyte infections caused by epidermophyton, microsporum, and trichophyton. It is also active against P orbiculare but not against Candida. 

Ketoconazole is effective in the therapy of cutaneous infections caused by epidermophyton, microsporum, and trichophyton species. Infections of the glabrous skin often respond within 2-3 weeks to a once-daily oral dose of 200 mg. Palmar-plantar skin is slower to respond, often taking 4-6 weeks at a dosage of 200 mg twice daily. Infections of the hair and nails may take even longer before resolving, with low cure rates noted for tinea capitis. Tinea versicolor is responsive to short courses of a once-daily dose of 200 mg. 

Antifungals applied topically are used to treat dermatophytic infections caused by Trichophyton and Microsporum species. Ringworm is the most common and widely known of such fungal skin diseases of animals and birds. In recent years, a number of reports have appeared drawing attention to the high incidence of human ringworm caused by fungi from animals. The public health aspects of the disease is of considerable importance, whereas the economic impact to the farmer is yet not clearly defined. 

Class Synthetic broad-spectrum antifungal agent with clinical activity against Blastomyces derrnatitidis. Candida specks, Coccidioides immitis, Histoplasma capsulatum, Paracoccidioides brasiliensis. Phialophora species, Trichophyton species, Epidermophyton specks, and Microsporum species... 

The most common fungal disease of veterinary importance is ringworm. This is often seen in young calves, and in domestic animals (dog and cat), from which it may be transmitted to humans. The organisms responsible are Microsporum or Trichophyton species. Infection results in an unsightly skin lesion. 

Three highly purified preparations catalyzing the deamination of ATP, ADP, and AMP have been isolated from Porphyra crispata (red marine alga) 182), Microsporum audouini (188), and De ulfovibrio desulfuri-cans (grown anaerobically) (184). 

Griseofulvin (Fulvicin and Grisactin) is a fungistatic effective against various dermatophytes, including Microsporum, Epidermophyton, and Trichophyton, that produce diseases of the skin, hair, and nails. It exerts its effect by inhibiting fungal mitosis. 

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