Microsporum spp

Fluconazole is fungistatic at therapeutic concentrations and has good activity against Candida albicans infections. However, some non-albican Candida species (e.g. C. glabrata, C. parapsilosis, C. krusei and C. tropicalis] are less sensitive to fluconazole. Fluconazole is active against Trichophyton spp. Cryptococcus neoformans, Histoplasma capsulatum, Microsporum spp. and Epidermophyton spp. Fluconazole, however, has no useful activity against moulds such as Aspergillus spp. 

Garlic has in vitro antifungal effects against Cryptococcus neoformans, Candida spp., Trichophyton, Epidermophyton, Microsporum, Aspergillus spp., and Mucor pusillus (40). When five volunteers consumed 10-25 mL of fresh garlic extract, urine samples had antifungal activity, but susceptibility from serum samples dropped significantly (42). 

Tolnaftate is a synthetic antifungal agent with a narrow spectrum of activity which is limited to dermatophytes (Epidermophyton, Microsporum and Trichophyton spp.). It could be used to treat mild localized dermatophytic infection. For topical application to dogs, tolnaftate is formulated as a 1% cream containing both polyethylene glycol and propylene glycol. The powder aerosol preparation is less likely to be effective for treatment, but could be applied to prevent spread of the infection. 

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