In living tissue

Although silk and cotton are classified as nonabsorbable sutures, these do lose strength gradually in living tissue and slowly break up after long periods of implantation (18). The USP specifications for Class I nonabsorbable sutures (silk or synthetic fibers) are shown in Table 4. 

Cysteine [52-90 ] is a thiol-bearing amino acid which is readily isolated from the hydrolysis of protein. There ate only small amounts of cysteine and its disulfide, cystine, in living tissue (7). Glutathione [70-18-8] contains a mercaptomethyl group, HSCH2, and is a commonly found tripeptide in plants and animals. Coenzyme A [85-61-0] is another naturally occurring thiol that plays a central role in the synthesis and degradation of fatty acids. 

Bioaccumulation-Accumulation of a chemical substance in living tissue. 

The strength of an acid depends on the solvent and an acid that is strong in water may be weak in another solvent or vice versa (see Section 10.8). However, because almost all reactions in living tissues and most reactions in laboratories take place in water, in almost every case the only solvent we consider in this chapter will be water. 

Chance, B., Leigh, J.S., Kent, J., McCully, K., Nioka, S., Clark, B.J., Marris, J.M., Graham, T. (1986). Multiple controls of oxidative metabolism in living tissues as studied by phosphorous magnetic resonance. Proc. Natl. Acad. Sci. USA 83,9458-9462. 

They are coccoid-shaped organisms and the feature which at one time consigned them to the virus class was the fact that they would only reproduce in living tissue. 

This group of microorganisms shares with chlamydias the property of growing only in living tissue. Rickettsiae occur as small (0.3 x 0.25/mi) rod-shaped or coccoid cells. They can be stained by special procedures. Division is by binary fission. They may be cultivated in the blood of laboratory animals or in the yolk sac of the embryo of the domestic fowl, and it is by this method that the organism is grown to produce vaccines. 

Anandamide is found in human brain 100 pmol/g in the hippocampus, 75 pmol/g in the thalamus, 60 pmol/g in the cerebellum, and 55 pmol/g in the striatum (Martin, 1999). The concentration of AEA increases postmortem, especially when the brain is kept at ambient temperature. Furthermore, AEA surges are observed when cerebellar granule cells are treated in hypoxic conditions (Hillard, 1997). Although such concentration increases may be artifacts of postmortem brain damage, they may also occur in living tissue under certain conditions, such as hypoxia. 

POPs are organic chemical substances that resist biodegradation, are toxic to both humans and wildlife and furthermore tend to accumulate in living tissues. 

Taken together, the field is now well placed to design new biosensors, examine protein-protein and protein-lipid interactions, and sensitively determine protein conformation in living tissues at submicron resolution. These interactions are either impossible or extraordinarily difficult to examine in other ways, and the subcel-lular resolution of FRET-FLIM that allows detection of interactions in specific subcellular compartments may provide insight that... 

Measurement of blue and green fluorescence of NADH and FAD in living tissues Quantitative fluorescent cytochemistry Using permeable fluorogenic substrates of enzymes, specific inhibitors, and kinetic analysis... 

The most important concept with respect to arsenic cycling in the environment is constant change. Arsenic is ubiquitous in living tissue and is constantly being oxidized, reduced, or otherwise... 

Inadvertent contact of a water-reactive material with water is obviously the most important issue regarding what can go wrong. Due to the prevalence of water in living tissues, water-reactive materials are often toxic or corrosive as well, so loss of containment is often an additional concern. The following are some of the possible causes of uncontrolled reactions associated with water-reactive materials ... 

Bioaccumulation An enrichment of a particular chemical caused by either passive adsorption from seawater or active uptake followed by retention in living tissues or hard parts as a result of nonexcretion. 

NADH/NADPH SURFACE FLUORESCENCE IN LIVING TISSUES... 

Mitochondrial oxidation-reduction state, NADH/NADPH SURFACE FLUORESCENCE IN LIVING TISSUES MITOGEN-ACTIVATED PROTEIN KINASE... 

There are two main ways in which light can react with a sensitiser and ground state triplet oxygen and so cause damage in living tissue. 

Problem 22.47 Write the structural formulas for adenine monophosphate (amp) and triphosphate (atp) nucleotides, (atp is the most important source of energy for biochemical processes in living tissues the energy comes from the breaking of the high-energy polyphosphate bonds.)... 

Corrosive The term refers to a chemical that causes visible destruction of, or irreversible alterations in, living tissue by chemical action at the site of contact. For example, a chemical is considered to be corrosive if, when tested on the intact skin of albino rabbits by the method described by the U.S. Department of Transportation in Appendix A to 49 CFR Part 173, it destroys or changes irreversibly the structure of the tissue at the site of contact following an exposure period of four hours. 

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