Paracoccidioides brasiliensis

Miconazole. Miconazole (Fig. 2, 7a) is also available as a sterile solution for intravenous infusion. Miconazole has a therapeutic effect on systemic mycoses due to C albicans A.spergillusfumigatus Cyptococcus neoformans Blastomyces dermatitidis Histoplasma capsulatum Coccidioides immitis Paracoccidioides brasiliensis and Petriellidum boydii. 

Class Synthetic broad-spectrum antifungal agent with clinical activity against Blastomyces derrnatitidis. Candida specks, Coccidioides immitis, Histoplasma capsulatum, Paracoccidioides brasiliensis. Phialophora species, Trichophyton species, Epidermophyton specks, and Microsporum species... 

Serologically active galactomannans, purified by way of their insoluble Fehling complexes, were obtained from mycelial and yeastlike forms of Paracoccidioides brasiliensis and Blastomyces dermaditidis, and shown by methylation analysis to consist of galactofuranosyl and mannopyranosyl units attached to a mannan core.142... 

Habitat of Paracoccidioides brasiliensis is the soil of semitropical areas along rivers and agricultural areas in Latin America. In children, acute dissemination causes severe illness, often associated with pustules or subcutaneous abscesses. In adults (mainly males) - usually many years after an asymptomatic primary pulmonary infection - chronic disseminated disease leads to mucocutaneous lesions (ulcerating papules and pustules, subcutaneous cold abscesses, sometimes scrofuloderma-like manifestations), especially around nose or mouth in about half of the patients. Itraconazole is the drug of choice. 

T. beigelii, T. capitatum Cryptococcus neoformans Coccidioides immitis Paracoccidioides brasiliensis Histoplasma capsulatum Torulopsis glabrata Mucor indicus Prototheca wickerhamii Prototheca zopfii... 

ANTIFUNGAL ACTIVITY Azoles are active against C. albicans, C. tropicalis, C. parap-silosis, C. glabrata, C. neoformans, Blastomyces dermatitidis, Histoplasma capsulatum, Coccid-ioides species, Paracoccidioides brasiliensis, and dermatophytes. Aspergillus spp., Scedosporium apiospermum (Pseudallescheria boydii), Fusarium, and Sporothrix schenckii are intermediate in susceptibihty. C. krusei and the agents of mucormycosis are resistant. 

DOC Paracoccidioides brasiliensis, thrush (pharyngeal Candida). Also for Tx of chronic mucocutaneous candidiasis, dermatophytes (including griseofulvin-resistant). 

In some yeasts, such as the pathogen Paracoccidioides brasiliensis, there is usually a good deal of wall glucan and it may exceed the amount of mannan yet a mutant is known which appears to have a wall composed wholly of mannan, without loss either of shape or pathogenicity. Similar structural mutants of S. cerevw/ae have been studied in some detail (Cohen, Zhang and Ballou, 1982). 

Silva CL, Alves EMC, Figueiredo F (1994) Involvement of cell wall glucans in the genesis and persistence of the inflammatory reaction caused by the fungus Paracoccidioides brasiliensis. Microbiology 140 1189-1194... 

Memnoniella Meria coniospora Metarhizium anisopliae Myrothecium Nigrospora Oidiodendron oryzae Paecilomyces lilacinus Paracoccidioides brasiliensis (Y)... 

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