Histoplasma capsulatum

Miconazole. Miconazole (Fig. 2, 7a) is also available as a sterile solution for intravenous infusion. Miconazole has a therapeutic effect on systemic mycoses due to C albicans A.spergillusfumigatus Cyptococcus neoformans Blastomyces dermatitidis Histoplasma capsulatum Coccidioides immitis Paracoccidioides brasiliensis and Petriellidum boydii. 

Caruso, M., Sacco, M., Medoff, G., Maresca, B. (1987). Heat shock 70 gene is differently expressed in Histoplasma capsulatum strains with different levels of thermotolerance and pathogenicity. Mol. Microbiol. 1, 151-158. 

S. Lavie and G. Stotzky, Interactions between clay minerals and siderophores affect the respiration of Histoplasma capsulatum. Appl. Environ. Microbiol. 51 65 (1986). 

Carter, D.A., Burt, A., Taylor, J.W., Koenig, G.L. and White, T.J. (1996) Clinical isolates of Histoplasma capsulatum from Indianapolis have a recombining population structure. Journal of Clinical Microbiology 34, 2577-2584. 

Material Safety Data Sheet-Infectious Substances Histoplasma capsulatum. March 2001. 

Histoplasmosis is caused by inhalation of dust-borne microconidia of the dimorphic fungus Histoplasma capsulatum. 

Data from Deepe CS. Histoplasma capsulatum. In Mandell CL, Bennett JE, Dolin % eds. Principles and Practice of Infectious Diseases, 6th ed. Philadelphia, PA Churchill Livingstone, 2005 3012-3026 Wheat J, Sarosi C, McKinsey D, et al. Practice guidelines for the management of patients with histoplasmosis. Oin Infect Dis 2000 30 688-695 Wheat U, Kauffman CA. Histoplasmosis. Infect Dis Oin North Am 2003 17(1) 1-19. 

Amphotericin B is used to treat systemic disseminated fungal infections caused by Candida spp., Cryptococcus neoformans, and the invasive dimorphic fungi Aspergillus spp., Histoplasma capsulatum, Coccidioides immi-tis, Blastomyces dermatitidis, and Sporothrix schenckii). Intravenous amphotericin B remains the treatment of choice for serious invasive fungal infections unresponsive to other agents. 

Histoplasma capsulatum, Cryptococcus neoformans, Candida albicans, Sporotrichum schenkii, Blastomyces brasiliensis, Coccidioides immitis, Rhodotorula, Aspergillus etc. It is fungicidal at high and fungistatic at low concentration. 

Noncultivable or slow-growing organisms (Histoplasma capsulatum, Bartonella or Brucella species), in which cultures are often discarded before sufficient growth has occurred for detection... 

Class Synthetic broad-spectrum antifungal agent with clinical activity against Blastomyces derrnatitidis. Candida specks, Coccidioides immitis, Histoplasma capsulatum, Paracoccidioides brasiliensis. Phialophora species, Trichophyton species, Epidermophyton specks, and Microsporum species... 

Histoplasma capsulatum Histoplasmosis Hitec heat-transfer salt Hitec Salt HIV HIV-1 Hi-Vegi-Lip Hrvol-44... 

Pneumocystis carini pneumonia (PCP), the most common of the opportunistic infections, occurs in more than 80% of AIDS patients (13). Toxoplasmosis, a protozoan infection of the central nervous system, is activated in AIDS patients when the CD4+ count drops and severe impairment of cell-mediated immunity occurs. Typically, patients have a mass lesion(s) in the brain. These mass lesions usually respond well to therapy and can disappear completely. Fungal infections, such as Cyptococcalmeningitis, are extremely common in AIDS patients, and Histoplasma capsulatum appears when cell-mediated immunity has been destroyed by the HIV virus, leading to widespread infection of the lungs, liver, spleen, lymph nodes, and bone marrow. AIDS patients are particularly susceptible to bacteremia caused by nontyphoidal strains of Salmonella. Bacteremia may be cleared by using antibiotic therapy. 

Histoplasma capsulatum Affects various tissues including lungs, lymphatics, and mucocutaneous tissues also causes blood dyscrasias (anemias, leucopenia] Amphotericin B or itraconazole... 

In a pattern very similar to that seen for MK-0911, isolates of Histoplasma capsulatum, Bipolaris spp., Cladophiahphora bantiana, Pseudallescheria boydii,... 

Histoplasma capsulatum CD4 count < 100/p.L, endemic geographic area... 

Histoplasma capsulatum var. duboisii causes African histoplasmosis, skin manifestations being the prominent sign in this variant. Three patterns may be differentiated clinically superficial (ulcerating papules or nodules, infiltrated plaques, target phenomenon ), subcutaneous granulomas (first hot and tender, then cold, rupture) and osteomyelitic lesions, the latter often demanding surgical procedures combined with amphotericin B and ketoconazole. 

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