Peritoneal macrophage

Macrophage (peritoneal, pleural, alveolar spaces) Histiocytes (tissues) Monocytes (blood) some cell-mediated responses)... 

Muramyl dipeptide derivatives have also been microencapsulated in lactide/glycolide copolymers for use alone as an immuno potentiator. L-lactide/glycolide copolymers were used to deliver MDP-B30, a lipophilic compound, from very small microspheres (less than 5 pm in diameter). The amount of MDP-B30 required for tumor growth inhibitory activity of mouse peritoneal macrophages was 2000 times less for the controlled release MDP-B30 microspheres than for the unen-capsulated drug (134). 

Finbloom DS, Metzger H Binding of immunoglobulin E to the receptor on rat peritoneal macrophages. J Immunol 1982 129 2004-2008. 

Squirrel monkey aorta smooth muscle cells Rat peritoneal macrophages (6)... 

Immunological tests were performed for studying the reactive of peritoneal-exudative cells, especially peritonial macrophages, which are the main effector cells involved in natural resistance (host defence system) against bacterial infection. 

Immunological tests indicated that fraction 1, obtaned by gel chromatography had an immunostimulating activity. It induced migration of peritoneal-exudative cells, respectively peritoneal macrophages into the peritoneal cavity of experimental animals. These cells are with high bactericidic metabolitic activity. 

Mouse peritoneal macrophages that have been activated to produce nitric oxide by 7-interferon and lipopolysac-charide were shown to oxidize LDL less readily than unactivated macrophages. Inhibition of nitric oxide synthesis in the same model was shown to enhance LDL oxidation (Jessup etal., 1992 Yates a al., 1992). It has recently been demonstrated that nitric oxide is able to inhibit lipid peroxidation directly within LDL (Ho etal., 1993c). Nitric oxide probably reacts with the propagating peroxyl radicals thus terminating the chain of lipid peroxidation. The rate constant for the reaction between nitric oxide and peroxyl radicals has recently been determined to be 1-3 X10 M" s (Padmaja and Huie, 1993). This... 

Johnson, N.F. and Davies, R. (1981). An ultrastructural study of the effect of asbestos fibres on cultured peritoneal macrophages. Br. J. Exp. Path. 62, 559-570. 

Many of the manifestations of intraabdominal infections, particularly peritonitis, result from cytokine activity. Inflammatory cytokines are produced by macrophages and neutrophils in... 

Intratracheal instillation 60 d Peritoneal macrophages dose-depen-dent, agglomeration-dependent inflammation (TNF-a up-regulation) [68]... 

Stimulation of murine peritoneal macrophages with IFNy and LPS induced NO synthesis and activated IRE binding by IRP-1 and IRP-2. This activation is NO dependent and accompanied by a loss of the aconitase activity of IRP-1. This was also shown to occur in other cell types, such as the erythroid cell line K562, rat brain slices and mouse fibroblast lines and did not require cytokine stimulation. The activating effects of NO may depend on a direct interaction with the 4Fe-4S cluster or a slow effect on the low-molecular-weight iron pool. Activation of IRP-2 by LPS and IFN-y has not been universally confirmed (reviewed by Cairo and Pietrangelo, 2000). 

LOX-dependent superoxide production was also registered under ex vivo conditions [55]. It has been shown that the intravenous administration of lipopolysaccharide to rats stimulated superoxide production by alveolar and peritoneal macrophages. O Donnell and Azzi [56] proposed that a relatively high rate of superoxide production by cultured human fibroblasts in the presence of NADH was relevant to 15-LOX-catalyzed oxidation of unsaturated acids and was independent of NADPH oxidase, prostaglandin H synthase, xanthine oxidase, and cytochrome P-450 activation or mitochondrial respiration. LOX might also be involved in the superoxide production by epidermal growth factor-stimulated pheochromo-cytoma cells [57]. 

In 1989, we showed [142] that the Fe2+(rutin)2 complex is a more effective inhibitor than rutin of asbestos-induced erythrocyte hemolysis and asbestos-stimulated oxygen radical production by rat peritoneal macrophages. Later on, to evaluate the mechanisms of antioxidant activities of iron rutin and copper-rutin complexes, we compared the effects of these complexes on iron-dependent liposomal and microsomal lipid peroxidation [165], It was found that the iron rutin complex was by two to three times a more efficient inhibitor of liposomal peroxidation than the copper-rutin complex, while the opposite tendency was observed in NADPH-dependent microsomal peroxidation. On the other hand, the copper rutin complex was much more effective than the iron rutin complex in the suppression of microsomal superoxide production, indicating that the copper rutin complex indeed acquired additional SOD-dismuting activity because superoxide is an initiator of NADPH-dependent... 

Iron-, copper-, and zinc complexes of rutin, dihydroquercetin, and green tea epicatechins were found to be much more efficient inhibitors than parent flavonoids of toxic effects of chrysotile asbestos fibers on peritoneal macrophages and erythrocytes [168], It was proposed that in this case the enhanced activity of metal-flavonoid complexes was increased by the absorption on chrysotile fibers. 

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