Lipid peroxidation inhibition

Probucol, another di-r-butyl phenol, is an anti-atherosclerotic agent that can suppress the oxidation of low-density lipoprotein (LDL) in addition to lowering cholesterol levels. The antioxidant activity of probucol was measured, using EPR, with oxidation of methyl linoleate that was encapsulated in liposomal membranes or dissolved in hexane. Probucol suppressed ffee-radical-mediated oxidation. Its antioxidant activity was 17-fold less than that of tocopherol. This difference was less in liposomes than in hexane solution. Probucol suppressed the oxidation of LDL as efficiently as tocopherol. This work implies that physical factors as well as chemical reactivity are important in determining overall lipid peroxidation inhibition activity (Gotoh et al., 1992). 

Broussochalcone A (32) Antioxidant activity (inhibition of lipid peroxidation) Inhibition of cyclooxygenase Inhibition of nitric oxide production Inhibition of respiratory burst in neutrophils Platelet aggregation inhibitory activity1 [42] [431 [42] [44] [431... 

Ray S, Sengupta C, Roy K. 2008. QSAR modeling for lipid peroxidation inhibition potential of flavonoids using topological and structural parameters. Cent Eur J Chem 6 267-276. 

Several members of the Cuparene class of sesquiterpenoids show interesting biological activity, including potent antifungal, neurotrophic and lipid peroxidation inhibition activity. Moreover, the presence of a hindered, quaternary... 

There is also evidence that the neuroprotective properties of lipid-peroxidation-inhibiting doses of methylprednisolone, extensively studied in spinal-cord injury, are applicable to brain injury. The steroid has been shown to enhance the early recovery of mice subjected to a moderately severe concussive head injury when administered at 5 minutes post-injury [59], The dose-response curve for this effect is remarkably similar to that discussed above for spinal-cord injury. A 30mg/kg i.v. dose was observed to be optimal, while lower (15 mg/kg) and higher (60 and 120 mg/kg) doses were ineffective. 

Gneafricanins A, C-E and F (560, 562-565), longusol A (577) and bisisorhapontigenin B (518) all exhibited a considerable degree of activity in lipid peroxide inhibition and superoxide dismutases (SOD) like antioxidant activity [211]. Bisisorhapontigenins E-G and 13b-methoxy bisisorhapontigenin G (523-526) all possessed potent antioxidant activity compared with vitamin E [253]. 

Mitochondrial effects GSH depletion ATP depletion Phospholipid modifications Heat shock protein modifications Lipid peroxidation Inhibition of membrane potential Ca release into cytosol... 

Lliya I. et al. [54] found that many stilbenes showed potential antioxidant activities by comparing the antioxidant activities of nine compounds including monomers 2, 5, 6, dimmer 10, trimmers gnemonol B (70), I (71), K (72) and 20 with Vitamin E for lipid peroxide inhibition and super oxide scavenging activity [10]. 

Compounds Super oxide scavenging actmty[lC >(uM)l Lipid peroxide inhibition activityriCsn(uM)l DPPH radical [SC, (pM)]... 

Cmpd Ri r2 r3 Lipid peroxidation inhibition IC50 (jiM) DPPH scavenging IC50 (pM) ABTS4 TEAC scavenging ... 

Many types of liver injury are caused by a number of biochemical reactions of toxicants or their active metabolites. Such reactions inclnde covalent binding, lipid peroxidation, inhibition of protein synthesis, pertnrbation of calcium homeostasis, disturbance of biliary prodnction, and a variety of immunologic reactions. The types of liver injury from such biochemical reactions include steatosis (fatty liver), liver necrosis, cirrhosis, cholestasis, hepatitis, and carcinogenesis. The toxicants that cause these injuries are discussed in brief. 

SPs not only function as dietary fiber, but they also contribute to the antioxidant activity of marine algae. It has been demonstrated that SPs have potential antioxidant activity and various classes of SPs including fucoidan, laminaran, and alginic acid have been shown as potent antioxidants (Rocha de Souza et ah, 2007 Ruperez et ah, 2002 Wang et ah, 2008). Antioxidant activity of SPs have been determined by various methods such as l,l-diphenyl-2-picryl hydrazil (DPPH) radical scavenging, lipid peroxidation inhibition, ferric reducing antioxidant power (FRAP), nitric... 

Allspice oleoresin gave a positive result in the DNA-repair test but not in the Ames Salmonella reversion assay or the Bacillus subtilis rec assay (Sekizawa and Shibamoto 1982). Antimutagenicity via antioxidant activity of allspice was observed in the DPPH radical reduction assay and lipid peroxidation inhibition testing (Ramos et al. 2003). 

Lovell, M. A., C. Xie, andW. R. Markesbery. Acrolein, a product of lipid peroxidation, inhibits glucose and glutamate uptake in primary neuronal cultures. 29(8),... 

DPHH assay. The peppermint oil shows a lipid peroxidation inhibition of 50% compared with 77% of the standard. 

The antioxidant capacity of anthocyanins has been demonstrated by radical scavenging of reactive oxygen species, reducing capacity, inhibition, or delaying of lipoprotein oxidation and platelet aggregation. Anthocyanins as individual compounds or present in a more complex extract have been found to play a role in the prevention of cardiovascular diseases and to be involved in several different events like the prevention of DNA damage, estrogenic activity, enzymatic inhibition, anti-inflammation response, lipid peroxidation inhibition, etc. [3-7]. 

ETWl and ETW2 (mannans) Edwardsiella tarda scavenging capacities on DPPH and hydroxyl radicals, and lipid peroxidation inhibition in-vitro [110]... 

Experimentally, the substances were studied in vivo on rats at a dose equivalent to 10 mg/kg of the pharmacon per os. The total antioxidant activity of the blood plasma was assessed by a method based on the ability of the biological agents to inhibit the accumulation of lipid peroxidation products in a suspension of egg-yolk lipoproteins [44]. the maximum percentage of the lipid-peroxidation inhibition (in relation to the outcome) observed for nine hours of the experiment, served as an index of the antioxidant activity. 

Terao, J. Piskula, M.K. (1999). Flavonoids and membrane lipid peroxidation inhibition. Nutrition, 15, 790-791. 

Atalay et al. (2011) determined the lipid peroxidation inhibition potential for nine lichen compounds in two lipid peroxidation test systems (liposome and emulsion systems). They found that isidiophorin, rhizonaldehyde, rhizonyl alcohol and pulmonarianin retarded lipid peroxidation at in both test systems. However, stictic acid and ergosterol peroxide exhibited antioxidant activity in only the liposome test system. Usnic acid and diffractaic acid were not antioxidants in either system, while stictic acid was not lipid peroxidation inhibitor in the emulsion test system. All compounds, which inhibited lipid peroxidation in both test systems, were also DPPH radical scavengers. 

An infusion of the pods inhibited the in vitro proliferation of mouse hepatocellular tumor (Tl) cells and induced apoptosis in the cells. The crude polyphenol fraction of carob pods exhibits in vitro lipid peroxidation-inhibiting, antioxidant, and free radical scavenging activities. ... 

In vitro antioxidant, lipid peroxidation-inhibiting, and copper chelating activities were found from aqueous extracts of the leaves and roots. ... 

Alcoholic extracts of the roots and leaves of E. angustifolia, E. pallida, and E. purpurea exhibited comparable in vitro antioxidant activities in ABTS free radical scavenging assay, and the root extracts were also active in the lipid peroxidation inhibition assay.Methanolic extracts of freeze-dried roots of the three species act as in vitro antioxidants through the scavenging of DPPH and ABTS radicals, as well as by chelation of the copper ion (Cu Copper-catalyzed oxidation of human LDL was further demonstrated in vitro by different preparations from E. purpurea root containing alkamides, caffeoyl derivatives, and polysaccharides, as well as by pure caffeoyl derivatives. The antioxidant effect was synergistic and dose dependent. ... 

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