Macrophages, mouse peritoneal

Muramyl dipeptide derivatives have also been microencapsulated in lactide/glycolide copolymers for use alone as an immuno potentiator. L-lactide/glycolide copolymers were used to deliver MDP-B30, a lipophilic compound, from very small microspheres (less than 5 pm in diameter). The amount of MDP-B30 required for tumor growth inhibitory activity of mouse peritoneal macrophages was 2000 times less for the controlled release MDP-B30 microspheres than for the unen-capsulated drug (134). 

Mouse peritoneal macrophages that have been activated to produce nitric oxide by 7-interferon and lipopolysac-charide were shown to oxidize LDL less readily than unactivated macrophages. Inhibition of nitric oxide synthesis in the same model was shown to enhance LDL oxidation (Jessup etal., 1992 Yates a al., 1992). It has recently been demonstrated that nitric oxide is able to inhibit lipid peroxidation directly within LDL (Ho etal., 1993c). Nitric oxide probably reacts with the propagating peroxyl radicals thus terminating the chain of lipid peroxidation. The rate constant for the reaction between nitric oxide and peroxyl radicals has recently been determined to be 1-3 X10 M" s (Padmaja and Huie, 1993). This... 

PAF synthesis can be demonstrated upon the appropriate stimulation of a diverse range of cells, including rat and mouse peritoneal macrophages [22], mouse bone marrow-derived mast cells [23, 24], rat kidney cells [25], human cultured lymphoid cell lines [26] and endothelial cells [27-29], human and... 

Laskin, D.L., Laskin, J.D., Weinstein, I.B. and Carchman, R.A. (1981). Induction of chemotaxis in mouse peritoneal macrophages by phorbolester tumor promoters. Cancer Res. 41 1923. 

Nishikawa, K., Arai, H., and Inoue, K., 1990, Scavenger receptor-mediated uptake and metabohsm of lipid vesicles containing acidic phosphohpids by mouse peritoneal macrophages./. Biol. Chem. 265 5226-5231. 

Gomez-Munoz, A., Martens, J.S., and Steinbrecher, U.P., 2000, Stimulation of phospholipase D activity by oxidized LDL in mouse peritoneal macrophages, Arterioscler. Thromb. Vasc.Biol. 20 135-143. 

IC50 concentration causing 50% loss of viability of mouse peritoneal macrophages, using the MTT test, after the incubation times stated. 

Wild-type and AmB-resistant (AmB-R) strains of L. donovani MHOM/IN/80/DD8 growing in mouse peritoneal macrophages were used. IC50 values calculated according to Ref. 31 were obtained after four days of incubation with the formulations. 

Poole B, Ohkuma S. Effect of weak bases on the intralysosomal pH in mouse peritoneal macrophages. J Cell Biol 1981 90 665-669. 

Probucol, a hypocholesterolemic drug that possesses antioxidant activity, inhibits the ex vivo release of IL-1 from LPS-stimulated macrophages of mice pretreated orally with 100 mg/kg/day of this compound [94,95]. This compound has been shown to inhibit LPS-induced zinc-lowering effect, is cited as direct evidence for the inhibition of IL-1 release, and may be useful candidate for the treatment of atherosclerosis [95,96]. An amino-dithiol-one derivative (RP 54745) blocked the proliferative action of IL-1 P on murine thymocytes in vitro and also inhibited the production of IL-1 in mouse peritoneal macrophages in vitro and in vivo. The compound RP 54745 selectively inhibited the expression of IL-la and IL-1 3 mRNA while TNFa mRNA was unaffected [97, 98]. 

In a study on the immunotoxic effects of cigarette tar components, hydroquinone, at a concentration that did not affect the viability of the cells (50 pmol/L), decreased IL-2-dependent DNA synthesis and cell proliferation by > 90% in cultured human T lymphoblasts (Li et al., 1997). Hydroquinone inhibited Fc-receptor-mediated phagocytosis in mouse peritoneal macrophages only at rather high concentrations (100 pmol/L) (Manning et al., 1994). 

Manning, B.W., Adams, D.O. Lewis, J.G. (1994) Effects of benzene metabolites on receptor-mediated phagocytosis and cytoskeletal integrity in mouse peritoneal macrophages. Toxicol, appl. Pharmacol., 126, 214-223... 

Knight D, Zheng X, Rocchini C, Jacobson M, Bai T, Walker B (1997) Adenosine A3 receptor stimulation inhibits migration of human eosinophils. J Leukoc Biol 62(4) 465-468 Kreckler LM, Wan TC, Ge Z-D, Auchampach JA (2006) Adenosine inhibits tumor necrosis factor-a release from mouse peritoneal macrophages via A2a and A2B but not the A3 adenosine receptor. J Pharmacol Exp Ther 317(1) 172—180... 

Rungby J, Hultman P, Ellermann-Eriksen S. 1987. Silver affects viability and structure of cultured mouse peritoneal macrophages and peroxidative capacity of whole mouse liver. Arch Toxicol 59 408-412. 

Gomez-Munoz A., O Brien L., Hundal R., and Steinbrecher U. P. (1999). Lysophosphatidylcholine stimulates phospholipase D activity in mouse peritoneal macrophages. J. Lipid Res. 40 ... 

Takagi, T., Hashiguchi, M, Mahato, R.I., Tokuda, H., Takakura, Y. and Hashida, M. (1998b) Involvement of specific mechanism in plasmid DNA uptake by mouse peritoneal macrophages. Biochem. Biophys. Res. Commun., 245, 729-733. 

Davenas E, Poitevin B, Benveniste J. 1987. Effect on mouse peritoneal macrophages of orally-administered very high dilutions of silicea. Eur J Pharmacol 135 313-319. 

Inspired by earlier work on galactose-conjugated chitosans, Hashimoto and coworkers [135] synthesized mannose-grafted chitosan (53-kDa) conjugates (man-chitosan) to deliver pDNA in mouse peritoneal macrophages that express the mannose receptor. Here, man-chitosan containing either 5% or 21%... 

Hashimoto M, Morimoto M, Saimoto H et al (2006) Gene transfer by DNA/mannosylated chitosan complexes into mouse peritoneal macrophages. Biotechnol Lett 28(11) 815—821... 

We have demonstrated that human monocyte derived macrophages (HMDMs) isolated from NIDDM patients after consumption of PJ for 3 months, the carotid lesion derived after endartherectomy from CAS patients that consumed PJ (Figure 8.4A), and also mouse peritoneal macrophages (MPMs) isolated from E° mice after consumption of PJ concentrate (12.5 pL/mouse/day, equivalent to 0.35 pmol of total... 

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