Lung tumors keratin

Epithelioid sarcoma Young adults. Deep soft tissue of extremities. Metastases to lung, lymph node, skin. Epithelioid tumor cells, granuloma-like growth pattern Keratin+, EMA+, vimentin+, CD34+, CK5/6-, p63- Nothing specific EM may be helpful... 

Nearly all small-cell neuroendocrine carcinomas (SCNCs) involving the mediastinum are metastatic, usually from tumors of the lungs or esophagus. Immunophenotypically, SCNC commonly demonstrates perinuclear punctate labeling for keratin (Fig. 

Basaloid squamous cell carcinoma (BSCC) also may be either a primary thymic tumor > ° or a mediastinal metastasis from a primary neoplasm of the oropharynx, hypopharynx, larynx, esophagus, lungs, or anorectal region. Keratin is universally present in BSCC with a diffuse cytoplasmic pattern of labeling, and reactivity for epithelial membrane antigen, keratin 5/6, and p63 may also be observed. h78,80,8i author s experi-... 

S-100 protein, HMB-45, and light chain immunoglobulin (evaluated in 1 case). In this author s experience with 6 cases primary in the lung, 5 showed immunostaining for vimentin (Fig. 12.31) and 1 showed coexpression of vimentin and keratin. Miyagi and associates described 3 cases of primary lung rhabdoid tumor, all associated with an adenocarcinoma. The authors concluded that the rhabdoid cells in these cases represented dedifferentiated components of an adenocarcinoma. 

Desmoplatic small round cell tumors occur primarily in the abdominal cavity.The neoplasms characteristically show immunostaining for desmin (a dotlike pattern), WTl, keratin, neuron-specific enolase, CD99, and actin. They also show the EWS-WTl gene fusion transcript. A desmoplastic, small, round cell tumor was reported primary in the lung by Syed and coworkers.Ultrastructurally, this tumor showed intracytoplasmic whorls of intermediate filaments, presumably desmin. A desmoplastic, small, round cell tumor was also reported as a primary neoplasm in the pleura. 

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