Lung tumors neuroendocrine differentiation

Wick MR, Berg LC, Hertz ML Large cell carcinoma of the lung with neuroendocrine differentiation A comparison with large cell undifferentiated pulmonary tumors. Am J Clin Pathol. 1992 97 796-805. 

Small cell neuroendocrine carcinoma (SCNEC) of the larynx is rare, representing less than 1% of all laryngeal carcinomas. These tumors have been categorized in a similar fashion to lung tumors, into oat cell type, intermediate, and combined. The first two tumor types have typical neuroendocrine differentiation and show... 

Matsuki and colleagues evaluated histidine decarboxylase, an enzyme of the amine precursor uptake and decarboxylation system known to be distributed in mast cells and enterochromaffin-like cells, with the hypothesis that this enzyme was a marker for neuroendocrine differentiation. The authors found that the anti-histidine decarboxylase antibody stained most small cell lung cancers (18 of 23 sensitivity 0.78) and was rarely reactive with non-neuroendocrine lung tumors... 

Somatostatin receptor type 2 somatostatin receptor type 2 (SST2) is a member of the somatostatin family, commonly detected in neuroendocrine tumors including small cell carcinoma of the lung. Some poorly differentiated non-neuroendocrine lung cancers show also weak expression of SST2. 

The immunohistogram of common non-neuroendocrine lung neoplasms is shown in Fig. 12.2. Additional immu-nohistochemical findings in lung neoplasms are listed in Table 12.8). 70-37 Jablg 23 shows an update on the differential expression of TTF-1, CK7, and CK20 in common primary and metastatic tumors of the lung. 

These highly aggressive and rapidly fatal tumors constitute less than 1% of all pancreatic endocrine neoplasms. They are so uncommon that some authors believe a poorly differentiated neuroendocrine carcinoma occurring in the pancreas is most likely a metastasis from an occult primary in the lung. However, there are proven cases of primary in this region." " Many are in fact of ampullary origin, and few are pancreatic. 

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