Lung tumors thyroid transcription factor

Liu J, Farhood A. Immunostaining for thyroid transcription factor-1 on fine-needle aspiration specimens of lung tumors a comparison of direct smears and cell block preparations. Cancer 2004 102 109-114. 

Thyroid transcription factor-1 (TTF-1), a nuclear tissue-specific protein transcription factor, is found in thyroid and thyroid tumors regardless of histologic type (except anaplastic type), as well as in lung carcinomas including adenocarcinomas (75%), non-small cell carcinomas (63%), neuroendocrine and small cell carcinomas (>90%), and squamous cell carcinomas (10%).258-258 Selectively expressed during embryogenesis in the thyroid, the diencephalon of the brain, and in respiratory epithelium, TTF-1 binds to and activates factors for surfactant protein derived from Clara cells.255 TTF-1 is rarely seen in carcinomas outside of the lung or thyroid... 

Rare cases of lung carcinoma can metastasize to the head and neck, particularly to the low cervical lymph nodes. These tumors usually carry the same immunophenotype as the primary lung tumor. Typical stains that are used to aid in this differential diagnosis will include cytokeratin 7, cytokeratin 20, and thyroid transcription factor-1 (TTF-1). 

Byrd-Gloster AL, Khoor A, Glass LE, et al. Differential expression of thyroid transcription factor-I in small cell lung carcinoma and Merkel cell tumor. Hum Pathol. 2000 31 58-62. Agoff SN, Lamps LW, Philip AT, et al. Thyroid transcription factor-1 is expressed in extrapulmonary small cell carcinomas but not in other extrapulmonary NE tumors. Mod Pathol. 2000 13 238-242. 

Thyroid transcription factor-1 (TTF-1) Lung cancer (adenocarcinoma, small cell carcinoma), thyroid tumors Small cell carcinoma of different locations Type II pneumocytes and Clara cells of lung, thyroid follicular and parafollicular C cells, diencephalon... 

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