Lung tumors tumor-associated glycoprotein

Cadherins. Cadherins are a group of glycoproteins that facilitate Ca2+-dependent cell-cell adhesive interactions.20 When cadherin function is disrupted, the release of a tumor cell can result. It was shown that the aggressive metastasis of undifferentiated epithelial carcinoma cells that had lost cell-cell adhesion could be stopped by transfection with E-cad-herin cDNA.21 Therefore, it was suggested that E-cadherin suppresses metastasis,22 which was further supported by more recent studies that showed the loss of adhesion of human gastric, prostatic, and lung cancer cells was due to the gene mutation of a protein associated with the proper function of cadherin.23... 

Kostakoglu L, Kiratli P, Ruacan S, Hayran M, Emri S, Ergun EL et al. Association of tumor washout rates and accumulation of technetium-99m-MIBI with expression og P-glycoprotein in lung cancer. J Nucl Med 1998 39 228 234. 

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