Tumor tracheal

NPIP induces esophageal and nasal cavity tumors in the rat, forestomach, liver and lung tumors in the mouse, and tracheal tumors in the Syrian golden hamster (43, 44, 45). Its potent carcinogenicity is indicated by the fact that a single dose of only 22 mg/kg was sufficient to induce tumors in 20% of Syrian golden hamsters (45). The environmental occurrence of NPIP appears to be less frequent than that of NPYR, but it has been detected in food (J, 44). 

Foreign body or tumor in tracheal or bronchial obstruction... 

NMOR is a potent hepatocarcinogen in the rat and induces tracheal and nasal cavity tumors in the Syrian golden hamster (43, 44, 45). It is formed readily from nitrite and morpholine in vitro and administration of these precursors to rodents causes tumors indicative of NMOR formation in vivo (44, 55, 56), NMOR has been detected in crankcase emissions of diesel engines and in factories engaged in rubber and tire manufacturing (57, 58). 

Exposed female mice had significant compound-related increases in nasal carcinomas (NTP 1982 Stinson et al. 1981). The incidences of combined alveolar/bronchiolar carcinoma and adenoma were significantly increased in the lungs of high-dose male and female mice as compared with control animals. In addition to these tumors, adenomatous polyps were present in tracheal, bronchial, and bronchiolar lumens (NTP 1982). 

Mossman, B. T., J. M. Landesman, and J. E. Craighead (1981). Asbestos exhibits properties of a classical tumor promotor on hamster tracheal epithelial cells. Proc. Am. Assoc. Cancer Res. Clin. 22 129. 

Beryllium metal, beryllium-aluminum alloy, beryl ore, beryllium chloride, beryllium fluoride, beryllium hydroxide, beryllium sulfate, and beryllium oxide all produce lung tumors in rats exposed by inhalation or intra-tracheally. The oxide and the sulfate produce lung tumors in monkeys after intrabronchial implantation or inhalation. A number of compounds produce osteosarcomas in rabbits after their intravenous or intramedullary administration. ... 

NNN induces esophageal and nasal cavity tumors in rats,tracheal timiors in hamsters, and lung adenomas in strain A mice. NNK is more tumorigenic than NNN in strain A mice and NNA is inactive in this species. NAB is less carcinogenic than NNN in both rats... 

Lymphocytes, platelets, endothelial cells, fibroblast, hepatocytes, astrocytes, intestine, Madin-Darby canine kidney (MDCK) cells, tracheal ciliary epithelia, choroid plexus, eye lens, frog skin, frog urinary bladder, Ehrlich ascites tumor cells Activation of KCI cotransport... 

Russell JP, Diamond G, Tarver AP, Scanlin TB, Bevins CL Coordinate induction of two antibiotic genes in tracheal epithelial cells exposed to the inflammatory mediators lipopolysaccharide and tumor necrosis factor alpha. Infect Immun 1996 64 1565-1568. 

Mossman BT, Craighead JE. 1979. Use of hamster tracheal organ cultures for assessing the cocarcinogenic effects of inorganic particulates on the respiratory epithelium. Prog Exp Tumor Res 24 37-47. 

Cosma GN, Marchok AC. 1987. The induction of growth-altered cell populations (tumor-initiation sites) in rat tracheal implants exposed to benzo(a)pyrene and formaldehyde. Carcinogenesis 8 1951-1953. 

Feron and Kruysse (3A08) conducted inhalation and intratracheal experiments with two groups of 18 male and 18 female 6-wk old Syrian hamsters. One group was exposed to 9.2 mg/m (4 ppm) of acrolein in air (7 hr/day, 5 d/wk, 52 wk). The other group was similarly exposed to acrolein via inhalation but received an intratracheal installation of 0.9% saline. All animals alive at 81 wk were sacrificed. Only one female had a tracheal papilloma. Tumors at other sites were not increased untreated controls. 

Patients who develop tracheal obstruction as a result of local invasion of an esophageal tumor, or after placement of a metallic stent in the esophagus. 

George and colleagues (1992) treated nine patients with malignant central airway obstruction due to tracheal (n=3) or main bronchial ( =6) stenosis with Gianturco stents. All patients suffered from severe dyspnea or asphyxia (four were emergency treatments). All patients had dramatic and rapid reUef of their symptoms after stent insertion. Two patients with intraluminal tumor growth required additional endobronchial measures to control local tumor progression. Patients survived between 3 weeks and 8 months after the intervention. Causes of death were cachexia or pneumonia. 

Kawabata Y, Iwai K, Udagawa T, Tukagoshi K, Kazue H. Effects of diesel soot on unscheduled DNA synthesis of tracheal epithelium and lung tumor formation. In ... 

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