Lung tumors antigens

Brichory, F., et al., "Proteomics-Based Identification of Protein Gene Product 9.5 as a Tumor Antigen that Induces a Humoral Immune Response in Lung Cancer," Cancer Res., 61, 7908-7912 (2001). 

Brichory F, Beer D, Le Naour F, Giordano T, Hanash S. (2001) Proteomics-based identification of protein gene product 9.5 as a tumor antigen that induces a humoral immune response in lung cancer. Cancer Res 61, 7908-12. 

Cole SP, Mirski S, McGarry RC, et al. Differential expression of the Leu-7 antigen on human lung tumor cells. Cancer Res. 1985 45 4285-4290. 

Gure AO, Stockert E, Scanlan MJ, Keresztes RS, Jager D, Al-torki NK, Old LJ, Chen YT (2000) Serological identification of embryonic neural proteins as highly immunogenic tumor antigens in small cell lung cancer Proc Natl Acad Sci USA 97 4198-4203... 

Methods Used to Identify Specific Tumor Antigens for Use in Lung Cancer Genetic Immunotherapy... 

Lou, Y., Vitalis, T. Z., Basha, G., Cai, B., Chen, S. S., Choi, K. B., Jeffries, A. P., Elliott, W. M., Atkins, D., Seliger, B., and Jefferies, W. A., 2005, Restoration of the expression of transporters associated with antigen processing in lung carcinoma increases tumor-specific immune responses and survival, Cancer Res. 65 7926-7933. 

Nofetumomab is a mouse monoclonal antibody coupled to 99mTc that is used for diagnostic purposes to determine extent of disease and to stage patients with small cell lung cancer. It binds a 40-kD antigen found on many tumor cell types, but also on some normal cells. It is an accurate indicator of extent of disease in biopsy-confirmed small cell lung cancer except in those patients with brain or adrenal metastases. 

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