Lamotrigin

Na+ channels at clinically relevant concentrations (carbamazepine, phenytoin, lamotrigine). Most of these anticonvulsant dtugs display three distinct effects on Na+ channels ... [Pg.127]

When carbamazepine is administered with primidone, decreased primidone levels and higher carbamazepine serum levels may result. Cimetidine administered with carbamazepine may result in an increase in plasma levels of carbamazepine that can lead to toxicity. Blood levels of lamotrigine increase when the agent is administered with valproic acid, requiring a lower dosage of lamotrigine... [Pg.258]

The nurse may give lamotrigine without regard to meals. However, it is important to give carbamazepine with meals to decrease gastric upset. The nurse can crush the tablets if the patient has difficulty swallowing. However, it is important not to crush or chew extended-released carbamazepine... [Pg.260]

CH6N4 79-17-4) see Ambazone Lamotrigine aminoguanidine carbonate (C2HSN4O3 2200-97-7) see Guanabenz... [Pg.2294]

CO2 124-38-9) see p-Aminosalicylic acid Gentisic acid Indecainide Lamotrigine Salicylic acid Troglitazone L-Tryptophan carbon disulfide... [Pg.2321]

CCuN 544-92-3) see Cinoxacin Citalopram Lamotrigine Mabuterol Methallenestril Trimetrexate glucuronate Corey lactone... [Pg.2338]

Other systems also interact with glutamate. Activation of L-type voltagegated calcium channels (VGCC) occurs with NMDA receptor activation. Lamotrigine blocks several ion channels, including P- and N-type VGCC channels, an action that blocks the euphoric effects of ketamine and reduces dysphoric and cognitive effects (Hundt et al. 1998). Other modulatory sites,... [Pg.13]

Vigabatrin (not marketed in United States), tiagabine, topiramate, gabapentin, carbamazepine, lamotrigine... [Pg.195]

Simpson DM, Olney R et al (2000) A placebo-controlled trial of lamotrigine for painful HIV-associated neuropathy. Neurology 54(11) 2115-2119 Simpson DM, Katzenstein D et al (2001) Plasma carnitine in HIV-associated neuropathy. AIDS 15(16) 2207-2208... [Pg.84]

Inhibition of glutamate release was thought to be the mode of action of lamotrigine. It reduces MBS and kindling and also glutamate (and to a lesser extent GABA) release induced in brain slices by veratridine, which opens sodium channels. But it now seems likely that the actual block of sodium channels is its primary action (see later). [Pg.340]

One unwanted side-effect of phenytoin is its anti-folate activity. A programme of synthetic chemistry to manipulate the structure of the anti-folate compound pyri-methium to try to replace that property with anticonvulsant activity resulted in the synthesis of lamotrigine. It proved to be an effective AED in partial and generalised epilepsy but experience has found it also to be of value in absence seizures. [Pg.347]

Calabresi, P, Centonze, D, Marfia, GA, Pisani, A and Bernardi, G (1999) An in vitro electro-physiological study on the effects of phenytoin, lamotrigine and gabapentia on striatal neurons. Brit. J. Pharmacol. 126 689-696. [Pg.350]

Epilepsy is a clinical disorder characterized by spontaneous, recurrent seizures arising from excessive electrical activity in certain parts of the brain [51]. Currently available drugs, such as phenytoin, carbamazepine, valproic acid, lamotrigine, and topiramate (for molecular structures see Fig. 6), provide symptomatic seizure suppression in only 60-70% of those receiving treatment [52-54]. These drugs are also associated with unwanted side... [Pg.85]

Allopurinol, barbiturates, carbamazepine, cephalosporins, cyclophosphamide, ethambutol, fluconazole, ibuprofen, lamotrigine, macrolides, nitrofurantoin, penicillins, phenytoin, propranolol, quinolones, sulfonamide antimicrobials, sulindac, tetracyclines, thiazides, valproic acid, and vancomycin... [Pg.101]

Antipsychotics, bromocriptine, carbamazepine, chlorpropamide, cyclophosphamide, desmopressin, ecstasy, lamotrigine, monamine oxidase inhibitors, NSAIDs, oxcarbazepine, oxytocin, tricyclic antidepressants, selective serotonin reuptake inhibitors, vasopressin, vinblastine, and vincristine... [Pg.169]

Myoclonic Not mentioned Lamotrigine Valproate Valproate Topiramate (children with severe myoclonic epilepsy of infancy) Second-line Clobazam6 Clonazepam Lamotrigine Levetiracetam Piracetam6 Topiramate... [Pg.451]

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