Lamotrigine guidelines

Treatment of depressive episodes in bipolar disorder patients presents a particular challenge because of the risk of a pharmacologic mood switch to mania, although there is not complete agreement about such risk. Treatment guidelines suggest lithium or lamotrigine as first-line therapy.17,41 Olanzapine has also demonstrated efficacy in treatment of bipolar depression, and quetiapine is under review for approval of treatment of bipolar depression.42 When these fail, efficacy data support use of antidepressants. 

U.K. guidelines Carbamazepine Lamotrigine Oxcarbazepine Topiramate Valproic acid ... 

U.K. guidelines Tiagabine Topiramate Zonisamide Children Gabapentin Lamotrigine Oxcarbazepine Topiramate Gabapentin ... 

Conversion from adjunctive therapy with valproate to monotherapy with lamotrigine Achieve a dosage of 200 mg/day of lamotrigine according the guidelines. While... 

Messenheimer JA, Guberman AH. Rash with lamotrigine dosing guidelines. Epilepsia 2000 41(4) 488. 

Drug overdose Of 16 796 toxic exposures to antiepileptic drugs (phenytoin, valproic acid, and carbamazepine) in the USA in 2006, 12 resulted in death, as reported by the US Toxic Surveillance System [67 ]. Some specific problems determined by overdose of some old and new antiepileptic drugs have been briefly reviewed. For example, topiramate can cause a significant metabolic acidosis, lamotrigine Stevens-Johnson syndrome, oxcarbazepine hyponatremia, and levetiracetam psychosis. Possible adoption of guidelines for critical care management of overdose are discussed. 

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