Lamotrigine Rifampicin

Ebert U, Thong NQ, Oertel R, et al. Effects of rifampicin and cimetidine on pharmacokinetics and pharmacodynamics of lamotrigine in healthy subjects. Eur J Clin Pharmacol 2000 56(4) 299-304. [Pg.122]

LAMOTRIGINE 1. ANTIBIOTICS -rifampicin 2. OESTROGENS 3. PROGESTOGENS 1 lamotrigine levels t metabolism Monitor levels... [Pg.219]

RIFAMPICIN LAMOTRIGINE l lamotrigine levels t metabolism Monitor levels... [Pg.536]

The effects of rifampicin on the pharmacokinetics of lamotrigine have been studied in 10 healthy men (73). [Pg.1998]

Rifampicin induced the glucuronidation of lamotrigine, increasing total clearance about two-fold. [Pg.1999]

Rifampicin markedly increased the clearance of lamotrigine in a pharmacokinetic study. A case report has described a similar finding, and also included some limited evidence suggesting that isoniazid may inhibit lamotrigine metabolism. [Pg.541]

Rifampicin increases the loss of lamotrigine from the body, probably by inducing glucuronidation via UDP-glucuronyl transferases. It was suggested that isoniazid may have inhibited lamotrigine metabolism. ... [Pg.541]

Information appears to be limited to these reports, but the interaction between lamotrigine and rifampicin would appear to be established. Be aware that rifampicin could reduce the efficacy of lamotrigine, and that increased lamotrigine doses are likely to be required. [Pg.541]

Armijo JA, Sanchez B, Peralta FG, Cuadrado A, Leno C. Lamotrigine interacticxi with rifampicin and isoniazid. A case report. (1996) 18(Si plC),... [Pg.541]

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