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Lamotrigine interactions

Oxcarbazepine Lamotrigine Interaction less marked than that caused by carbamazepine Induction of lamotrigine metabolism... [Pg.290]

Paracetamol Lamotrigine Interaction probably of little or no clinical significance Unknown... [Pg.291]

Other systems also interact with glutamate. Activation of L-type voltagegated calcium channels (VGCC) occurs with NMDA receptor activation. Lamotrigine blocks several ion channels, including P- and N-type VGCC channels, an action that blocks the euphoric effects of ketamine and reduces dysphoric and cognitive effects (Hundt et al. 1998). Other modulatory sites,... [Pg.13]

Depression is a common problem in patients with epilepsy, with approximately 30% having symptoms of major depression at some point.34 Patients with epilepsy should be routinely assessed for signs of depression, and treatment should be initiated if necessary. Certain AEDs may exacerbate depression, for example levetirac-etam and phenytoin. Other AEDs (e.g., lamotrigine, carba-mazepine, and oxcarbazepine) maybe useful in treating depression. Changes in mood can be precipitated by addition or discontinuation of an AED. If treatment for depression is necessary, caution should be exercised in choosing an agent that does not increase seizure frequency and does not interact with AEDs. [Pg.457]

Lamotrigine is not approved for the acute treatment of depression, and the dose must be started low and slowly titrated up to decrease adverse effects if used for maintenance therapy of bipolar I disorder. A drug interaction and a severe dermatologic rash may occur when lamotrigine is combined with valproate (i.e., lamotrigine doses must be halved from standard dosing titration). [Pg.591]

Use caution when combining with lamotrigine because of potential drug interaction. [Pg.780]

Drug interactions Diuretics" NSAIDs (e.g., ibuprofen)" Lamotrigine Clozapine" Contraceptives HIV protease inhibitors" ... [Pg.79]

II.e. 5.2. Interactions between first and second generation AEDs. Felbamate raises plasma concentrations of phenytoin, valproic acid and carbamazepine. Clearance of tiagabine, topiramate and zon-isamide is increased in the presence of an enzyme inducer. Vigabatrin reduces phenytoin concentrations after 4-5 weeks of comedication (via an unknown mechanism). For tiagabine, the elimination half-life may be reduced by 2-3 hours in the presence of an enzyme-induction AED. Lamotrigine elimination is slower if given with valproic acid. Topiramate reduces elimination of phenytoin. [Pg.690]

Phenobarbital Enhances phasic GABAa receptor responses reduces excitatory synaptic responses Nearly complete absorption not significantly bound to plasma proteins peak concentrations in Vi to 4 h no active metabolites tjy2 varies from 75 to 125 h Generalized tonic-clonic seizures, partial seizures, myoclonic seizures, generalized seizures, neonatal seizures, status epilepticus Toxicity Sedation, cognitive issues, ataxia, hyperactivity Interactions Valproate, carbamazepine, felbamate, phenytoin, cyclosporine, felodipine, lamotrigine, nifedipine, nimodipine, steroids, theophylline, verapamil, others... [Pg.529]

Lang, D. G., Wang, C. M., Cooper, B. R. Lamotrigine, phenytoin and carbamezepine interactions on the sodium current present in N4TG1 mouse neuroblastoma cells, J. Pharmacol. Exp. Therap. 1993, 266, 829-835. [Pg.328]

Anderson GC, Yau MK, Gidal BE, et al. Bidirectional interaction of valproate and lamotrigine in healthy subjects. Clin Pharmacol Ther 1996 60 145-156. [Pg.116]

Use alone or in combina tion with other drugs (e.g, lithiunry catbatnaz-epin antipsychoti(3) for the acute treatment of mania and for rtrainte-nance trealmenl Use caution when combining with lamotrigine because ot potential drug interaction. [Pg.767]

No likely pharmacokinetic interactions ot lamotrigine with lithium, atypical antipsychotics, or antidepressants... [Pg.238]

Valproate Lamotrigine Risk of toxicity therapeutic synergism possible Inhibition of lamotrigine metabolism and pharmacodynamic interaction... [Pg.291]

Pharmacodynamic interactions also occur. In particular, the adverse effects of any drug can be increased by other drugs with similar properties. One example is the reciprocal potentiation of the neurotoxic effects of carbamazepine and lamotrigine in patients taking a combination of these drugs (180). Some drugs (for example ciclosporin, clozapine) have a proconvulsant effect and can reduce the efficacy of antiepileptic drugs. [Pg.296]

Carbamazepine toxicity with lamotrigine pharmacokinetic or pharmacodynamic interaction Epilepsia... [Pg.301]

The most common adverse effects of lamotrigine include dizziness, weakness, headache, diplopia, ataxia, blurred vision, and somnolence (SEDA-18, 65) (SEDA-20, 63) (19). These effects resemble those seen with carbamaze-pine and can result from an adverse pharmacodynamic interaction. Tolerability is better when lamotrigine is given as monotherapy or with drugs other than carbama-zepine however, tremor develops in some patients taking valproate in combinations (SEDA-18, 66). During monotherapy, serum lamotrigine concentrations associated with intolerable adverse effects (mostly headache, dizziness, and ataxia) were 0.4-18.5 qg/ml and overlapped widely with those tolerated in other patients (20). [Pg.1992]

The interaction of methsuximide with lamotrigine has been studied in 16 patients aged 9-19 years with a variety... [Pg.1998]


See other pages where Lamotrigine interactions is mentioned: [Pg.93]    [Pg.93]    [Pg.349]    [Pg.457]    [Pg.599]    [Pg.600]    [Pg.339]    [Pg.220]    [Pg.1223]    [Pg.1230]    [Pg.1808]    [Pg.201]    [Pg.315]    [Pg.690]    [Pg.283]    [Pg.158]    [Pg.219]    [Pg.524]    [Pg.530]    [Pg.530]    [Pg.531]    [Pg.304]    [Pg.92]    [Pg.110]    [Pg.339]    [Pg.161]    [Pg.158]    [Pg.1667]    [Pg.1990]   
See also in sourсe #XX -- [ Pg.331 ]




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