Lamotrigine psychiatric symptoms

The addition of lamotrigine to clozapine therapy has been associated with rapid improvement of psychiatric symptoms (71) this has been observed in three cases of poor response or resistance to clozapine monotherapy. 

A 23-year-old woman with schizophrenia had worsening of psychiatric symptoms after exposure to lamotrigine (444). This patient was taking quetiapine 400 mg/day and... 

Villari V, Rocca P, Frieri T, Bogetto F. Psychiatric symptoms related to the use of lamotrigine a review of the literature. Funct Neurol 2008 23(3) 133-6. 

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