Sertraline Lamotrigine

Kaufman KR, Gerner R. Lamotrigine toxicity secondary to sertraline. Seizure 1998 7 163-165. 

Sertraline Carbamazepine Diazepam Lamotrigine Phenytoin Risk of toxicity of the object drugs Inhibition of metabolism of the object drugs... 

Lamotrigine Toxicity has been reported following the addition of sertraline. 

Antidepressants mirtazapine, nefazodone, sertraline Neuroleptics thioridazine, haloperidol, clozapine, quetiapine, risperidone, sertindole, ziprasidone Mood stabilizers carbamazepine, gabapentin, lamotrigine... 

Toxicity has been anecdotally reported with the combined use of lamotrigine and sertraline. 

The authors suggest that sertraline may competitively inhibit the glu-curonidation of lamotrigine. Evidence so far appears limited to this case report. In view of the increased risk of rash with increased lamotrigine levels (see also Lamotrigine + Valproate , below), it may be prudent to monitor the combination. Further study is needed. 

A slightly slower metabolism of lamotrigine with higher serum levels was noted in patients taking lamotrigine in combination with sertraline [82 ]. This was not thought to be clinically significant. 

Christensen J, Sandgaard AP, Sidenius P, Linnet K, Licht RW. Lack of interaction between sertraline and lamotrigine in psychiatric patients ... 

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