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Lamotrigine epilepsy

The traditional treatment of tonic-clonic seizures is phenytoin or phenobarbital however, the use of carbamazepine and valproic acid is increasing because these AEDs have a lower incidence of side effects and equal efficacy. Valproic acid generally is considered the drug of first choice for atonic seizures and for juvenile myoclonic epilepsy. Lamotrigine and perhaps topiramate and zonisamide may be alternative agents for these seizure types. [Pg.1033]

One unwanted side-effect of phenytoin is its anti-folate activity. A programme of synthetic chemistry to manipulate the structure of the anti-folate compound pyri-methium to try to replace that property with anticonvulsant activity resulted in the synthesis of lamotrigine. It proved to be an effective AED in partial and generalised epilepsy but experience has found it also to be of value in absence seizures. [Pg.347]

Epilepsy is a clinical disorder characterized by spontaneous, recurrent seizures arising from excessive electrical activity in certain parts of the brain [51]. Currently available drugs, such as phenytoin, carbamazepine, valproic acid, lamotrigine, and topiramate (for molecular structures see Fig. 6), provide symptomatic seizure suppression in only 60-70% of those receiving treatment [52-54]. These drugs are also associated with unwanted side... [Pg.85]

Myoclonic Not mentioned Lamotrigine Valproate Valproate Topiramate (children with severe myoclonic epilepsy of infancy) Second-line Clobazam6 Clonazepam Lamotrigine Levetiracetam Piracetam6 Topiramate... [Pg.451]

Depression is a common problem in patients with epilepsy, with approximately 30% having symptoms of major depression at some point.34 Patients with epilepsy should be routinely assessed for signs of depression, and treatment should be initiated if necessary. Certain AEDs may exacerbate depression, for example levetirac-etam and phenytoin. Other AEDs (e.g., lamotrigine, carba-mazepine, and oxcarbazepine) maybe useful in treating depression. Changes in mood can be precipitated by addition or discontinuation of an AED. If treatment for depression is necessary, caution should be exercised in choosing an agent that does not increase seizure frequency and does not interact with AEDs. [Pg.457]

Discontinuation strategy for patients with epilepsy If a decision is made to discontinue therapy with lamotrigine, a step-wise reduction of dose over at least 2... [Pg.1225]

Withdrawal seizures Do not abruptly discontinue AEDs because of the possibility of increasing seizure frequency in patients with epilepsy and weizures in bipolar patients. Unless safety concerns require a more rapid withdrawal, taper the dose of lamotrigine over a period of at least 2 weeks. [Pg.1229]

In normal dosages juvenile myoclonic epilepsy may be induced with lamotrigine. [Pg.689]

Lamotrigine has a broad spectrum of action and is effective in generalized and partial epilepsies. Its primary mechanism of action appears to be blockage of voltage-dependent sodium channels, although its effectiveness against absence seizures indicates that additional mechanisms may be active. Lamotrigine is almost completely... [Pg.379]

Rowan AJ, Ramsay RE, Collins JF, et. al. New onset geriatric epilepsy a randomized study of gabapentin, lamotrigine, and carbamazepine. Neurology 2005 64 1868-1873. [Pg.549]

Brodie MI, Overstall PW, Giorgi L, The UK Lamotrigine Elderly Study Group. Multicentre, double-blind, randomized comparison between lamotrigine and carbamazepine in elderly patients with newly diagnosed epilepsy. Epilepsy Res 1999 37 81-87. [Pg.674]

Brodie, M.J. and Yuen, A.W (1997) Lamotrigine substitution study evidence for synergism with sodium valproate 105 Study Group. Epilepsy Res 26 423 32. [Pg.323]

Isojarvi, J.I., Rattya, J., Myllyla, V.V., Knip, M., Koivunen, R., Pak-arinen, A.J., Tekay, A., and Tapanainen, J.S. (1998) Valproate, lamotrigine, and insulin-mediated risks in women with epilepsy. Ann Neurol 43 446-451. [Pg.325]

Lamotrigine is an anticonvulsant drug that attenuates some forms of cortical glutamate release via inhibition of sodium, calcium, and potassium channels. An open-label case series (Uvebrant and Bauziene, 1994) and a case report (Davanzo and King, 1996) described improvement in autistic symptoms and self-injurious behavior, irritability, disturbed sleep, and social impairment in autistic children and an 18-year-old female with profound mental retardation, respectively, who were treated for epilepsy. [Pg.574]

Uvebrant, P., and Bauziene, R. (1994) Intractable epilepsy in children the efficacy of lamotrigine treatment, including non-seizure-related benefits. Neuropediatrics 25 284—289. [Pg.578]

Schlumberger E, Chavez F, Palacios L, et al. Lamotrigine in treatment of 120 children with epilepsy. Epilepsia 1994 35 359-367. [Pg.224]

Specific myoclonic syndromes are usually treated with valproate an intravenous formulation can be used acutely if needed. It is nonsedating and can be dramatically effective. Other patients respond to clonazepam, nitrazepam, or other benzodiazepines, although high doses may be necessary, with accompanying drowsiness. Zonisamide and levetiracetam may be useful. Another specific myoclonic syndrome, juvenile myoclonic epilepsy, can be aggravated by phenytoin or carbamazepine valproate is the drug of choice followed by lamotrigine and topiramate. [Pg.528]

Lamictal (lamotrigine) for epilepsy, Lamisil (terbinafine) for nail infections, Ludiomil (maprotiline) for depression, and Lomotil (diphenoxylate) for diarrhea... [Pg.263]

Ueberall MA. Normal growth during lamotrigine monotherapy in pediatric epilepsy patients—a prospective evaluation of 103 children and adolescents. Epilepsy Res 2001 46(l) 63-7. [Pg.674]

Biton V, Mirza W, Montouris G, Vuong A, Hammer AE, Barrett PS. Weight change associated with valproate and lamotrigine monotherapy in patients with epilepsy. Neurology 2001 56(2) 172-7. [Pg.690]

Biton V, Levisohn P, Hoyler S, Vuong A, Hammer AE. Lamotrigine versus valproate monotherapy-associated weight change in adolescents with epilepsy results from a post hoc analysis of a randomized, double-blind clinical trial. J Child Neurol 2003 18 133-9. [Pg.690]

Gidal BE, Tamura T, Hammer A, Vuong A. Blood homocysteine, folate and vitamin B12 concentrations in patients with epilepsy receiving lamotrigine or sodium valproate for initial monotherapy. Epilepsy Res 2005 64 161-6. [Pg.691]

Vigabactin is indicated for second-line use in patients with refractory partial epilepsy but, unlike lamotrigine and topiramate, it does not appear to be useful in generalized epilepsies. It is the drug of choice for infantile spasms. [Pg.317]


See other pages where Lamotrigine epilepsy is mentioned: [Pg.86]    [Pg.86]    [Pg.127]    [Pg.349]    [Pg.452]    [Pg.183]    [Pg.339]    [Pg.596]    [Pg.60]    [Pg.1224]    [Pg.688]    [Pg.123]    [Pg.324]    [Pg.326]    [Pg.279]    [Pg.366]    [Pg.508]    [Pg.519]    [Pg.87]    [Pg.614]    [Pg.654]    [Pg.656]    [Pg.604]    [Pg.562]    [Pg.60]    [Pg.314]   
See also in sourсe #XX -- [ Pg.85 ]

See also in sourсe #XX -- [ Pg.1038 ]




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