Lamotrigine encephalopathy

Two patients (age unspecified) with severe epileptic encephalopathy who had improved on lamotrigine in combination with valproate developed continuous myoclonic jerks after 2-3 years these were ascribed to high serum concentrations of lamotrigine (65 and 69 pmol/l) (25). 

Severe encephalopathy due to lamotrigine overdose has been reported (70). 

Antiepileptic drug-induced encephalopathies have been reviewed [50 ]. These complications have been reported with phenytoin, carbamazepine, and valproate and less often with vigabatrin, lamotrigine, and topiramate. 

Drug-drug interactions Lamotrigine Polypharmacy with enzyme inducers is an important susceptibility factor for valproate encephalopathy. Valproic acid-induced hyperammonemic encephalopathy developed exclusively during concomitant treatment with lamotrigine + valproate in a psychiatric setting [174" ]. 

Fan CC, Huang MC, Liu HC. Lamotrigine might potentiate valproic acid-induced hyperammonemic encephalopathy. Prog Neuropsychopharmacol Biol Psychiatry 2008 32(7) 1747-8. 

Management of adverse drug reactions A case report of lamotrigine overdose resulted in encephalopathy and convulsions, but was successfully treated with 3 days of hemodialysis [84 ]. 

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