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Lamotrigine reactions

The most frequent side effects are diplopia, drowsiness, ataxia, and headache. Rashes are usually mild to moderate, but Stevens-Johnson reaction has also occurred. The incidence of the more serious rashes appears to be increased in patients who are also receiving valproic acid and who have rapid dosage titration. Valproic acid substantially inhibits the metabolism of lamotrigine. [Pg.607]

With phenytoin, carbamazepine, phenobarbital, primidone, and lamotrigine, hepatotoxicity usually occurs as part of a hypersensitivity reaction, with skin rashes and fever in the early weeks of treatment. More rarely, hepatic disease can develop after many years without signs of hypersensitivity. Once hepatotoxicity develops, mortality... [Pg.282]

The possibility of renal dysfunction as a rare adverse effect should be considered. The patient had a history of allergic reactions to lithium, carbamazepine, clozapine, haloperidol, and lamotrigine. [Pg.1467]

Liver toxicity from lamotrigine is extremely rare. Acute hepatic necrosis occurred in the context of a hypersensitivity reaction that also involved the skin (SEDA-20, 64). [Pg.1994]

Published and unpublished cases of Stevens-Johnson syndrome (n = 43) and toxic epidermal necrolysis (n = 14) associated with lamotrigine have been reviewed (44). The patients with Stevens-Johnson syndrome were younger than those with toxic epidermal necrolysis (21 versus 31 years) the median time to onset for both reactions was 17 days the median dosage at onset (50 mg for Stevens-Johnson syndrome, 87.5 mg for toxic epidermal necrolysis) did not differ significantly. Valproate comedication was present in 74% and 64% of patients with Stevens-Johnson syndrome and toxic epidermal necrolysis respectively. In three patients, toxic epidermal necrolysis occurred in the context of the anticonvulsant hypersensitivity syndrome. [Pg.1994]

Stevens-Johnson syndrome, and 3 as suggestive of Stevens-Johnson syndrome two deaths were reported. Rashes associated with one or more symptoms of hypersensitivity reactions occurred in 19 children. Of 29 patients with Stevens-Johnson syndrome, toxic epidermal necrolysis, or hypersensitivity reactions, for whom precise details were available, 83% were taking lamotrigine with concomitant valproate and 85% were taking lamotrigine dosages higher than recommended. [Pg.1995]

Co-administration of valproate is one of the most important risk factors for skin reactions to lamotrigine valproate co-medication was present in 74 and 64% of patients with Stevens-Johnson syndrome and toxic epidermal necrolysis respectively (44). [Pg.1999]

Twenty-six lamotrigine-associated reactions consistent with the features of the anticonvulsant hypersensitivity syndrome have been reviewed, including nine previously published (54). The patients were aged 3.5-74 years (mean 28) and 14 were female. Valproate was used as co-medication in 60%. [Pg.1999]

Catania S, Cross H, de Sousa C, Boyd S. Paradoxic reaction to lamotrigine in a child with benign focal epilepsy of childhood with centrotemporal spikes. Epilepsia 1999 40(ll) 1657-60. [Pg.2000]

Schlienger RG, Shapiro LE, Shear NH. Lamotrigine-induced severe cutaneous adverse reactions. Epilepsia 1998 39(Suppl 7) S22-6. [Pg.2000]

Sarris BM, Wong JG. Multisystem hypersensitivity reaction to lamotrigine. Neurology 1999 53(6) 1367. [Pg.2001]

Figure 21 Examples of unusual glucuronidation reactions lamotrigine (quaternary ammonium glucuronide) and sulfinpyrazone (carbon-linked glucuronide). ... Figure 21 Examples of unusual glucuronidation reactions lamotrigine (quaternary ammonium glucuronide) and sulfinpyrazone (carbon-linked glucuronide). ...
Lamotrigine is metabolized by hepatic microsomal oxidases, and is subsequently glu-curonidated in a phase II reaction. There is very little first-pass effect. [Pg.41]

A recent careful analysis of reported cases caused by antiepileptics, minocycline, allopurinol, and abacavir revealed quite consistent clinical pictures according to the eliciting drug, but also quite striking differences in the symptoms (Peyriere et al. 2006). For example, abacavir-induced reactions lack eosinophilia and hepatitis, but cause mainly gastrointestinal and respiratory symptoms, lamotrigine does (rarely) cause eosinophilia, while allopurinol-induced DRESS often involves the kidneys, etc. [Pg.49]

Another synthetic pathway to lamotrigine involves the synthesis of 3,5-disubstituted-l,2,4-triazines followed by amination by means of nucleophilic displacement of one or two leaving groups at positions 3 and 5, for instance, a chloro atom and the methylthio group, as shown in Scheme 194. Unfortunately, the amination procedure is not very smooth, and requires rather severe reaction conditions <1995MI3>. [Pg.185]

The serum levels of lamotrigine can be markedly increased by valproate. Concurrent use has been associated with skin rashes, tremor and other toxic reactions. Lamotrigine has been found to cause small increases, decreases or no changes in valproate levels. [Pg.542]

Comparative studies In an open study in patients with type I bipolar disorder randomized to lithium ( = 78) or lamotrigine (n = 78) and followed for up to 5 years, there was no overall difference, although lamotrigine was non-significantly better at preventing episodes of depression and lithium better at preventing episodes of mania [3 ]. Patients taking lithium had more adverse reactions, particularly diarrhea, tremor, polyuria, and thirst (serum concentrations maintained at 0.5-1.0 mmol/1). [Pg.26]

In an open trial of monotherapy with car-bamazepine, phenytoin, valproate, or lamo-trigine in 505 Chinese patients with newly diagnosed epilepsy [3 ], 18% had adverse reactions carbamazepine (25/168 15%), phenytoin (18/59 31%), valproate (32/192 17%), and lamotrigine (16/86 19%). The... [Pg.86]


See other pages where Lamotrigine reactions is mentioned: [Pg.452]    [Pg.184]    [Pg.786]    [Pg.1229]    [Pg.56]    [Pg.321]    [Pg.519]    [Pg.562]    [Pg.161]    [Pg.651]    [Pg.773]    [Pg.147]    [Pg.282]    [Pg.1990]    [Pg.1992]    [Pg.1995]    [Pg.1995]    [Pg.1996]    [Pg.1996]    [Pg.1039]    [Pg.1267]    [Pg.1276]    [Pg.1607]    [Pg.509]    [Pg.183]    [Pg.224]    [Pg.234]    [Pg.96]    [Pg.185]    [Pg.543]    [Pg.92]    [Pg.103]   


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