Antiepileptics lamotrigine

OESTROGENS ANTIEPILEPTICS-LAMOTRIGINE f lamotrigine levels T metabolism Monitor levels... 

PROGESTOGENS ANTIEPILEPTICS -LAMOTRIGINE 1 lamotrigine levels t metabolism Monitor level... 

Turning to the pharmacotherapy for mania, for decades lithium was the only effective drug treatment. More recently, a number of antiepileptic drugs including carba maze pine, lamotrigine and valproate have been shown to also act as mood stabilisers and are becoming established for the treatment and prophylaxis of both unipolar mania and bipolar manic depressive disorders. 

In addition to these drugs, many of the newer antiepileptic drugs such as lamotrigine have found a place in the therapeutic management of mania. These are extensively covered in Chapter 12. 

The apparent clearance of lamotrigine is affected by the coadministration of AEDs. Lamotrigine is eliminated more rapidly in patients who have been taking hepatic enzyme inducing antiepileptic drugs (ElAEDs), including carbamazepine, phenytoin, phenobarbital, and primidone. 

Curry, W.J. and Kulling, D.L. (1998) Newer antiepileptic drugs ga-bapentin, lamotrigine, felbamate, topiramate and fosphenytoin. Am Fam Physician 57 513-520. 

Three antiepileptic drugs have now been FDA approved as mood stabilizers for the prevention of recurring episodes of mania divalproex sodium (Depakote), extended-release carbamazepine (Equetro), and lamotrigine (Lamictal). Many of these drugs are prescribed to children for the control of epilepsy and, increasingly, for bipolar disorder. A critical question is their effect on the developing mental and emotional function of children, but there is little research on the subject (Loring, 2005). 

Equetro (extended-release carbam-azepine antiepileptic drug) Lamictal (lamotrigine antiepileptic drug)... 

Outlook Among the newer antiepileptics, gabapentin, oxycarbazepine, lamotrigine, and topiramate are now endorsed as primary monotherapeutics for both partial and generalized seizures. Their pharmacokinetic characteristics are generally more desirable than those of the older drugs. 

Should certain antiepileptic drugs be contraindicated in patients with active psychosis Unfortunately there is not enough solid information to answer this question. Undoubtedly, anticonvulsants that are less likely to cause psychosis (lamotrigine, carbamazepine, oxcarbaze-pine, valproate) should be preferred (52,53). However, patients with psychoses have been successfully treated even with drugs that are believed to be associated with psychosis, such as vigabatrin. For example, in a prospective study in 10 patients with psychosis and epilepsy to whom vigabatrin was added, there was no aggravation of the psychiatric disorder (54). 

BARBITURATES 1. CARBAMAZEPINE 2. LAMOTRIGINE 3. TIAGABINE 4. VALPROATE 5. ZONISAMIDE L levels of these antiepileptics Induction of metabolism Watch for poor response to these antiepileptics... 

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