Labetalol hydrochloride

Labetalol hydrochloride 20-80 mg IV bolus every 10 minutes 5-10 minutes 3-6 hours Vomiting, scalp tingling, dizziness, bronchoconstriction, nausea, heart block, orthostatic hypotension Most hypertensive emergencies except acute heart failure... 

T. J. Cholerton, J. H. Hunt, and M. Martin-Smith, Convenient gas chromatographic method for the proportions of the two racemic modifications present in labetalol hydrochloride, J. Chromatogr., 555 178 (1985). 

Frusemide is physically incompatible with diltiazem hydrochloride, dobutamine hydrochloride, dopamine hydrochloride, labetalol hydrochloride, midazolam hydrochloride, milrinone lactate, nicardipine hydrochloride, parenteral nutrient solutions, cisatracurium besylate, and vecuronium bromide. 

Heparin and its salts are incompatible with many drugs including alteplase, amikacin sulfate, amiodarone hydrochloride, ampicillin sodium, aprotinin, benzylpenicillin potassium or sodium, cephalothin sodium, ciprofloxacin lactate, cytarabine, dacarbazine, daunorubicin hydrochloride, diazepam, dobutamine hydrochloride, doxorubicin hydrochloride, droperidol, erythromycin lactobionate, gentamicin sulfate, haloperidol lactate, hyaluronidase, hydrocortisone sodium succinate, kanamycin sulfate, methicillin sodium, netilmicin sulfate, some opioid analgesics, oxytetracycline hydrochloride, some phenothiazines, polymyxin B sulfate, streptomycin sulfate, tetracycline hydrochloride, tobramycin sulfate, vancomycin hydrochloride, vinblastine sulfate, cisatracurium besylate, labetalol hydrochloride, nicardipine hydrochloride, cefmetazole, sodium ions, and fat emulsion.110 112... 

Labetalol hydrochloride is incompatible with 5% sodium bicarbonate injection. White precipitate is formed immediately in 5% glucose solutions of ffusemide (10 mg/mL), insulin (100 ml.), and thiopentone.117118... 

Warfarin sodium may be adsorbed to PVC and intravenous infusion sets but may be minimized with glass containers or polyethylene-lined containers. Warfarin sodium is incompatible with solutions of adrenaline hydrochloride, amikacin sulfate, metaraminol tartrate, oxytocin, promazine hydrochloride, tetracycline hydrochloride, aminophylline, bretylium tosylate, ceftazidime, cimetidine hydrochloride, ciprofloxacin lactate, dobutamine hydrochloride, esmolol hydrochloride, gentamicin sulfate, labetalol hydrochloride, metronidazole hydrochloride, and vancomycin hydrochloride.130131... 

P.-H.C. Yuen, et al., Compatibility and stability of labetalol hydrochloride in commonly used intravenous solutions. Am. J. Hosp. Pharmacol. 40 1007-1009, 1983. 

Dilevalol DBTA Salt to Dilevalol Hydrochloride. Very little improvement in the RR composition results from the transformation of dilevalol DBTA salt to dilevalol hydrochloride. Ethyl acetate was used as the solvent vehicle in early work. In a search for a more stable solvent methyl isobutyl ketone (MIBK) was selected as the best alternative. DBTA was removed by extraction into water with sodium hydroxide (DBTA of excellent quality was recovered from the aqueous phase in high yield >90%). The MIBK solution of dilevalol was then treated with hydrochloride acid to precipitate dilevalol hydrochloride (Scheme 9). The pH needed for maximum efficiency in the crystallization of dilevalol hydrochloride was 0.5 (this is in sharp contrast to the pH required for maximum efficiency in the crystallization of labetalol hydrochloride—pH 3.0). It should also be noted that dilevalol hydrochloride could not be handled in stainless steel equipment. Hastelloy, plastic or ceramic equipment was employed to eliminate the risk of coloration of dilevalol hydrochloride by traces of iron compounds. The plant equipment layout for this step is shown in Figure 5. 

Infra-red Spectrum. Principal peaks at wavenumbers 1680,1643, 1502, 1270, 820, 1250 (labetalol hydrochloride, Nujol mull). 

Labetalol hydrochloride is an alpha-adrenergic blocker/beta-adrenergic blocker that selectively blocks alpha-1 receptors and nonselectively blocks beta receptors to decrease BP, heart rate, and myocardial oxygen demand. It is indicated in the management of hypertension. 

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