Dopamine hydrochloride

Polar functional groups such as alcohols or phenols 11 or trimethylsilanol 4 are transformed by monofunctional silylating reagents Me3SiX 12 into their hpophilic and often volatile trimethylsilyl ethers 13 whereas water is converted into persilyl-ated water (=Me3SiOSiMe3, hexamethyldisiloxane, HMDSO, 7, b.p. 100 °C). The persilylation of phenols and, in particular, catechol (or hydroquinone) systems (Scheme 2.1) protects them efficiently against air oxidation even at temperatures of up to 180 °C. (cf, e.g., the silylation-amination of purine nucleosides with dopamine hydrochloride in Section 4.2.4)... 

Silylation-amination of 4(lH)-quinohnone 255 with a twofold excess of dopamine hydrochloride 256 as amine and an acidic catalyst affords, on heating with excess HMDS 2 for 21 h at 145 °C and subsequent transsilylation in excess boihng methanol, 75% of the crystalline hydrate of 257 (Scheme 4.28). The silylation-amination of 2-thio-6-azauracil 258 with homoveratrylamine 259, HMDS 2, and SnCLj as catalyst for 48 h at 145 °C furnishes 63% of the diamine 260, and MesSiOSiMes 7 and Me3SiSH or Me3SiSSiMe3 601 as leaving groups. 

A mixture of inosine 235a (5.346 g, 20mmol), HMDS 2 (16.77 mL, 80 mmol), dopamine-hydrochloride (7.586 g, 40 mmol), and (NH4)2S04 (0.264 g, 2 mmol) is boiled under reflux with magnetic stirring in an oil bath at 145 °C for 20 h, whereupon most of the NH4CI formed sublimes into the lower part of the reflux-condenser. The cooled mixture is transsilylated for 3 h with 400 mL boiling methanol,... 

FIG. 17 Chemical structures of (a) epinephrine hydrochloride, (b) dopamine hydrochloride, (c) isoproterenol hydrochloride, (d) phenylephrine hydrochloride, (e) tolazoline hydrochloride, (f) oxyprenolol hydrochloride, (g) alprenolol hydrochloride, and (h) propranolol hydrochloride. 

DOPAMINE HYDROCHLORIDE INJECTION USP 40MG/ML 10ML UNIT 10/PQ 6505011231060 PG 89.96 ... 

Cardiac sympathomimetics dobutamine hydrochloride dopamine hydrochloride eninephrine hydrochloride isoproterenol... 

Frusemide is physically incompatible with diltiazem hydrochloride, dobutamine hydrochloride, dopamine hydrochloride, labetalol hydrochloride, midazolam hydrochloride, milrinone lactate, nicardipine hydrochloride, parenteral nutrient solutions, cisatracurium besylate, and vecuronium bromide. 

These compounds have been obtained105 by bubbling [18F]F2 in neon through a solution of dopamine hydrochloride in anhydrous HF containing BF3, at-65°C (equation 51). PET scans showed that 6-[18F]FDA is a good tracer to study cardiac neuronal function. Routine injections of 5 mCi of 6-[18F]FDA will be possible by using the lsO (p, n) 18F nuclear reaction by irradiation of [180]02 thick targets106. 

Dose. Initially 2 to 5 pg/kg/min of dopamine hydrochloride, by intravenous infusion. 

Dopamine Hydrochloride Mannomustine Hydrochloride Sodium Cromoglycate Clidinium Bromide Decoquinate... 

Sautou-Miranda V, Gremeau 1, Chamard I, Cassagnes J, Chopineau J. Stability of dopamine hydrochloride and of dobutamine hydrochloride in plastic syringes and adrniriistration sets. Am J Health-Syst Pharm 1998 53 186-187. 

Dandurand KR, Stennett DJ. Stability of dopamine hydrochloride exposed to blue-light phototherapy. Am J Hosp Pharm 1985 42 595-597. 

Young L E, Blissitt K J, Clutton R E et al 1998 Haemodynamic effects of a sixty min infusion of dopamine hydrochloride in horses anaesthetised with halothane. Equine Veterinary Journal 30 310-316... 

Table 1. Estimation of DA in dopamine hydrochloride injection solution using...

At least eighteen phenylethylamines have been examined by x-ray crystallography. Among these are phenylethylamine hydrochloride (3 ), ephedrine hydrochloride (31), ephedrine monohydrogen phosphate monohydrate (32), ephedrine dihydrogen phosphate (33), dopamine hydrochloride (34), 5-hydroxydopamine hydrochloride (35), 6-hydroxydopamine hydrochloride (36), epinephrine hydrogen tartrate (37), norepinephrine hydrochloride (38), isoproterenol sulfate (39), 2,4,5-trimethoxyamphetamine hydrochloride (40), 4-ethyl-2,5-dimethoxyamphetamine (41), mescaline hydrobromide (42), and mescaline hydrochloride (43). 

Results for a variety of other adrenergic agents have been compiled in Table IV. As was the case for the amphetamines, the extended conformation is by far the predominant one, with conformer 11 making a substantial contribution in compounds bearing a hydroxyl group on C-2. The notable exception is dopamine hydrochloride, in which 43% of the extended conformation and 57% of the gauche conformation were observed. 

When the conformation of the ethylamine side-chain with respect to the aromatic nucleus is considered as the starting-point, the dopamine molecule may exist either in a trans (extended) conformation, or in a cis (gauche) conformation. Single crystal x-ray analysis of dopamine hydrochloride indicates that the ethylamine chain is in a nearly completely extended conformation which resides on a plane almost perpendicular to the plane of the catechol ring.93... 

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