Diltiazem hydrochloride

Katsumata, K., Katsumata, K. Jr and Katsumata Y. (1992). Protective efiect of diltiazem hydrochloride on the occurrence of alloxan- or streptozotocin-induced diabetes in rats. Horm. Metab. Res. 24, 508-510. 

Monograph 1004 (1997) Diltiazem hydrochloride. European Pharmacopoeia 3rd Edn, Council of Europe, Strasbourg. 

GA McClelland, SC Sutton, K Engle, GM Zentner. The solubility-modulated osmotic pump In vitro/in vivo release of diltiazem hydrochloride. Pharm Res 8 88-92, 1991. 

GM Zentner, GA McClelland, SC Sutton. Controlled porosity solubility- and resin-modulated osmotic delivery systems for release of diltiazem hydrochloride. J Controlled Release 16 237-244, 1991. 

Halloysite was found to be a viable and inexpensive nanoscale container for the encapsulation of biologically active molecules and drugs as was first demonstrated by Price et al. [5-8]. Its physicochemical characterization as a novel drug delivery system was also reported by Levis and Deasy et al. [9,10], who further demonstrated the controlled release of diltiazem hydrochloride and propanol hydrochloride... 

DILTIAZEM HYDROCHLORIDE INJECTION 5MG/ML 10ML VIAL 6 VIALS/PG 6505013539327 PG 157.92 ... 

An example of an industrial membrane bioreactor is the hollow-fiber membrane system for the production of (-)-MPGM (3-(4-methoxyphenyl)glycidic acid methyl ester), which is an important intermediate for the production of diltiazem hydrochloride [81, 82]. For the enantiospecific hydrolysis of MPGM a hollow-fiber ultrafiltration membrane with immobilized lipase from Serratia marcescens is used. (-f)-MPGM is selectively converted into (2S,3J )-(-F)-3-(4-methoxyphenyl)glyci-dic acid and methanol. The reactant is dissolved in toluene, whereas the hydrophilic product is removed via the aqueous phase at the permeate side of the membrane, see Fig. 13.9. EnantiomericaUy pure (-)-MPGM is obtained from the to-... 

Diltiazem Hydrochloride Cardizem SR 60, 90, 120 mg extended-release capsirles... 

Figure 4.7 Chromatograms from selected ion monitoring (a) VA-dimethylaminoethyl chloride (DMC), 200 pg corresponding to 0.2 ppm, operator 1 (b) dimethylaziridinium (DMA), 1 ng corresponding to 1 ppm, operator 1 (c) DMC, 200 pg, operator 2 (d) batch of diltiazem hydrochloride estimated to contain 0.06 ppm DMC (operator 1). Normal day-to-day variation in retention times is illustrated DMA elutes later than DMC (Rs = 1.6). Reproduced from [22] by permission of the Royal Society of Chemistry.

The adsorption isotherms of three basic drngs, the anxiolytic bnspirone hydrochloride, the antidepressant doxepin hydrochloride, and the Ca + blocker diltiazem hydrochloride, were fitted to the Bilangmnir model, as shown in Figure 10.12 [27]. This finding snggested that the adsorption took place on two different types of sites and that there were two different adsorption mechanisms. 

Calcium channel blockers amlodipine besylate diltiazem hydrochloride nifedipine... 

Vergote, G.J. Vervaet, C. Remon, J.P. etal., Near-infrared FT-Raman spectroscopy as a rapid analytical tool for the determination of diltiazem hydrochloride in tablets Eur. J. Pharm. Sci. 2002, 16, 63-67. 

A pulsatile release diltiazem hydrochloride dosage form with a blend of fast, medium, and slow release fractions of a multilayered diltiazem bead was designed.32 Polymeric membrane coating was applied to modulate the time of release. The fast, medium, and slow release fractions... 

The influence of surface active agents on the crystallinity of lyophilized diltiazem hydrochloride was examined by Seitakari et al. (38). As the concentration of either polysorbate 80 or poloxamer 188 was increased, the crystallinity of freeze-dried diltizem hydrochloride was found to increase. 

H Matsumae, M Furui, T Sabatani. Lipase-catalyzed asymmetric hydrolysis of 3-phenylglycidic acid ester, the key intermediate in the synthesis of diltiazem hydrochloride. J Ferment Bioeng 75 93-98, 1993. 

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