Hypericum

St. John s wort Hypericum Antidepressant and Usually mild. May May decrease efficacy of... [Pg.661]

Herbals Hypericum perforatum, L-carnitine/coenzyme QIO, Ginkgo biloba Study findings have been negative. [Pg.196]

Hypericin, from Hypericum perforatum (St. John s wort)... [Pg.5]

Hypericum perforatum L. Hypericaceae (St John s Wort) Unknown... [Pg.409]

Anand, R. et al.. Comparison of extraction techniques for extraction of bioactive molecules from Hypericum perforatum L. plant, J. Chromatogr. Sci., 43, 530, 2005. [Pg.500]

Dall Acqua F, see Gambari R (2007) 9 265-276 Daneshtalab M (2006) Novel Synthetic Antibacterial Agents. 2 153-206 Demirkiran O (2007) Xanthones in Hypericum Synthesis and Biological Activities. 9 139-178... [Pg.310]

Xanthones in Hypericum Synthesis and Biological Activities O. Demirkiran... [Pg.328]

Risperidone Aripiprazole 2D6 > 3A4 2D6, 3A4 Carbamazepine and phenytoin topiramate hypericum (St. John s Wort). Paroxetine, fluoxetine, sertraline (high dose) grapefruit juice 2D6 or 3A4 substrates acting as competitive inhibitors. [Pg.49]

A. Johne, J. Brockmoller, S. Bauer, A. Maurer, M. Langheinrich, and I. Root, Pharmacokinetic interaction of digoxin with an herbal extract from St. John s wort (Hypericum perforatum). Clin. Pharmacol. Ther., 66, 338-345 (1999). [Pg.126]

Arif Khan, Nick Redding and Walter A. Brown, 2008. Hypericum Depression Trial Study Group, 2002. [Pg.185]

Hudson, Christopher G., Socioeconomic Status and Mental Illness Tests of the Social Causation and Selection Hypotheses , American Journal of Orthopsychiatry 75, no. 1 (2005) 3-18 The Humble Humbug , The Lancet 2 (1954) 321 Hunter, Aimee M., Andrew F. Leuchter, Melinda L. Morgan and Ian A. Cook, Changes in Brain Function (Quantitative EEG Cordance) During Placebo Lead-in and Treatment Outcomes in Clinical Trials for Major Depression , American Journal of Psychiatry 163, no. 8 (2006) 1426-32 Hyland, Michael E., Do Person Variables Exist in Different Ways , American Psychologist 40 (1985) 1003-10 Hypericum Depression Trial Study Group, Effect of Hypericum Perforatum (St John s Wort) in Major Depressive Disorder A Randomized Controlled Trial , Journal of the American Medical Association 287 (2002) 1807-14... [Pg.204]

Philipp, Michael, Ralf Kohnen and Karl O. Hiller, Hypericum Extract Versus Imipramine or Placebo in Patients with Moderate Depression Randomised Multicentre Study ofTreatment for Eight Weeks , British Medical Journal 319 (1999) 1534-39... [Pg.212]

Hyperforin, the major constituent in Hypericum perforatum (St. John s Wort), inhibits the enzymatic activity of 5-lipoxygenase and COX-1 in platelets, acts as a dual inhibitor of 5-lipoxygenase and COX-1, and might have some potential in inflammatory and allergic diseases connected to eicosanoids (32), Several Hypericum species are of medicinal value in Asia and the Pacific. One of these is Hypericum erectum Thunb., the potential of which as a source of 5-lipoxygenase is given here. [Pg.41]

Hypericum erectum Thunb., or otogirisou (Japanese), is an herb of grassy places and thin woods in the hills and mountains of Japan, Korea, and China. The plant is a lithe herb with decussate leaves and yellow flowers (Fig. 17). In Japan, the juice expressed from the leaves is used to heal cuts and sooth bruises. A decoction of the fruits is used to stop bleeding. In Vietnam and Cambodia, a paste of the aerial parts is applied to dog... [Pg.42]

An TY, Ming DS, Hu LH, Liu SJ, Chen ZL. Polyprenylated phloroglucinol derivatives from Hypericum erectum. Phytochemistry 2002 59 395-398. [Pg.65]

In addition to this serious diet-drug interaction, irreversible MAOIs also potentiate the effects of sympathomimetic drugs like ephedrine found in over-the-counter cold remedies and recreational stimulants like amphetamine. The MAOIs also interact with drugs that increase synaptic concentrations of 5-HT, such as the tricyclic antidepressant clomipramine and the herbal SSRI antidepressant St John s wort (Hypericum spp.). The resulting serotonin syndrome is characterised by hyperthermia and muscle rigidity. While devoid of these side effects the reversible MAO-A inhibitor moclobemide has yet to establish itself as a first-line alternative to the SSRIs. [Pg.179]

Hypericum An extract of Hypericum perforatum (St John s wort) used in the phytotherapy of depression. [Pg.243]

Franklin G, Conceicao LF, Kombrink E and Dias AC. 2009. Xanthone biosynthesis in Hypericum perforatum cells provides antioxidant and antimicrobial protection upon biotic stress. Phytochem 70(l) 60-68. [Pg.352]

Hypericum, 73 356 Hyperlipidemias, 25 798 and obesity, 3 87 Hyperoxides, 73 392 Hyperparathyroidism, 25 793 Hypersensitivity reaction, immune-mediated, 25 205... [Pg.461]

The active components of the herbaceaous perennial plant Hypericum perforatum are antiinflammatory, antidepressive and healing agents, therefore, their analysis is of considerable importance for health care. Samples were prepared by extracting the dried flowering tops by hot methanol. RP-HPLC separations were performed in an ODS column (250 X 4.6 mm i.d. particle size 5 pm) thermostated at 30°C. The steps of gradient elution are listed in Table 2.49. [Pg.162]

A typical chromatogram representing the separation of Hypericum perforatum extract with the HPLC-MS attributions of the components detected is shown in Fig. 2.49. The validation parameters of the method (linearity, stability, reproducibility of the injection integration and repeatability, and robustness) were acceptable, therefore, it was found suitable for routine analysis of the composaition of the extracts of Hypericum perforatum [149],... [Pg.163]

Fig. 2.49. Profile of Hypericum perforatum extract with the H LC-MS attributions of the components detected. 1 = chlorogenic acid isomer 2 = 3-0- -coumaroylquinic acid 3 = chlorogenic acid 4 = rutin 5 = hyperoside 6 = isoquercitrin 7 = 3,3, , , 7-pentahydroxyflavanone 7-0-rhamnopyranoside 8 = quercitrin 9 = quercetin 10 = 13,118 tapigenin 11 = pSeudohypericin 12 = hypericin 13 = hyperforin analogue 14 = hyperform dialogue 15 = hyperforin 16 = adhyperforin. Reprinted with permission from M. Brolis eta. [ ].

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