Hypericum drummondii

A series of compounds which share many structural features occur in dicotyledonous plants. Drummondin A, B, and C [44,45, and 46, respectively, (Fig. 5.23)] from Hypericum drummondii (Clusiaceae) have significant activity against the gram-positive bacteria Staphylococcus aureus, Bacillus subtilis, and the acid-fast bacterium Mycobacterium smeg-matis. Japonicin A (47), from the same plant, has antimalar-ial activity. Robustaol A (48), from Eucalyptus robusta (Myrtaceae), has activity against Plasmodium berghei (Boris and Schaeffer, 1992). Similar compounds, isolated from Mallotus japonicus (Euphorbiaceae), have cytotoxic activity (Jayasuriya et al., 1989). 

Jayasuriya, H., j. D. McChesney, S. M. Swanson, and J. M. Pezzuto, Antimicrobial and cytotoxic activity of rottlerin-type compounds from Hypericum drummondii, J. Nat. Prod., 52, 325-331 (1989). 

Constit. of Hypericum drummondii. Antimicrobial and cytotoxic agent. Yellow cryst. (hexane). Mp 130-132°. 

Phytochemical studies of different species of Hypericum indicated that the genus is a valuable source of secondary metabolites, with peculiar chemical features. Several other prenylated phloroglucinols, not related to hyperforin and sometimes unique in their structure, have been identified in II. drummondii [53],//. brasiliense [54], and//, japonicum [55],... 

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See also in sourсe #XX -- [ , , , , ]

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ , ]

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