Hypericum perforatum

Herbals Hypericum perforatum, L-carnitine/coenzyme QIO, Ginkgo biloba Study findings have been negative. [Pg.196]

Hypericin, from Hypericum perforatum (St. John s wort)... [Pg.5]

Hypericum perforatum L. Hypericaceae (St John s Wort) Unknown... [Pg.409]

Anand, R. et al.. Comparison of extraction techniques for extraction of bioactive molecules from Hypericum perforatum L. plant, J. Chromatogr. Sci., 43, 530, 2005. [Pg.500]

A. Johne, J. Brockmoller, S. Bauer, A. Maurer, M. Langheinrich, and I. Root, Pharmacokinetic interaction of digoxin with an herbal extract from St. John s wort (Hypericum perforatum). Clin. Pharmacol. Ther., 66, 338-345 (1999). [Pg.126]

Hudson, Christopher G., Socioeconomic Status and Mental Illness Tests of the Social Causation and Selection Hypotheses , American Journal of Orthopsychiatry 75, no. 1 (2005) 3-18 The Humble Humbug , The Lancet 2 (1954) 321 Hunter, Aimee M., Andrew F. Leuchter, Melinda L. Morgan and Ian A. Cook, Changes in Brain Function (Quantitative EEG Cordance) During Placebo Lead-in and Treatment Outcomes in Clinical Trials for Major Depression , American Journal of Psychiatry 163, no. 8 (2006) 1426-32 Hyland, Michael E., Do Person Variables Exist in Different Ways , American Psychologist 40 (1985) 1003-10 Hypericum Depression Trial Study Group, Effect of Hypericum Perforatum (St John s Wort) in Major Depressive Disorder A Randomized Controlled Trial , Journal of the American Medical Association 287 (2002) 1807-14... [Pg.204]

Hyperforin, the major constituent in Hypericum perforatum (St. John s Wort), inhibits the enzymatic activity of 5-lipoxygenase and COX-1 in platelets, acts as a dual inhibitor of 5-lipoxygenase and COX-1, and might have some potential in inflammatory and allergic diseases connected to eicosanoids (32), Several Hypericum species are of medicinal value in Asia and the Pacific. One of these is Hypericum erectum Thunb., the potential of which as a source of 5-lipoxygenase is given here. [Pg.41]

Hypericum An extract of Hypericum perforatum (St John s wort) used in the phytotherapy of depression. [Pg.243]

Franklin G, Conceicao LF, Kombrink E and Dias AC. 2009. Xanthone biosynthesis in Hypericum perforatum cells provides antioxidant and antimicrobial protection upon biotic stress. Phytochem 70(l) 60-68. [Pg.352]

The active components of the herbaceaous perennial plant Hypericum perforatum are antiinflammatory, antidepressive and healing agents, therefore, their analysis is of considerable importance for health care. Samples were prepared by extracting the dried flowering tops by hot methanol. RP-HPLC separations were performed in an ODS column (250 X 4.6 mm i.d. particle size 5 pm) thermostated at 30°C. The steps of gradient elution are listed in Table 2.49. [Pg.162]

A typical chromatogram representing the separation of Hypericum perforatum extract with the HPLC-MS attributions of the components detected is shown in Fig. 2.49. The validation parameters of the method (linearity, stability, reproducibility of the injection integration and repeatability, and robustness) were acceptable, therefore, it was found suitable for routine analysis of the composaition of the extracts of Hypericum perforatum [149],... [Pg.163]

Fig. 2.49. Profile of Hypericum perforatum extract with the H LC-MS attributions of the components detected. 1 = chlorogenic acid isomer 2 = 3-0- -coumaroylquinic acid 3 = chlorogenic acid 4 = rutin 5 = hyperoside 6 = isoquercitrin 7 = 3,3, , , 7-pentahydroxyflavanone 7-0-rhamnopyranoside 8 = quercitrin 9 = quercetin 10 = 13,118 tapigenin 11 = pSeudohypericin 12 = hypericin 13 = hyperforin analogue 14 = hyperform dialogue 15 = hyperforin 16 = adhyperforin. Reprinted with permission from M. Brolis eta. [ ].

Farag M.A. Wessjohann L A. Metabolome classification of commercial hypericum perforatum (StJohn s Wort) preparations via UPLC-qTOF-MS and chemometrics. PlantaMedica, 2012, 78 (5), 488-496. [Pg.70]

Saint-John s-wort (Hypericum perforatum) is a perennial herb with round stems having two distinct lengthwise ridges (Kowalchik and Hylton 1987 Leyel 1994). It produces bright yellow flowers with five... [Pg.257]

Saint-John s-wort (Hypericum perforatum). Reprinted with permission from Sturdivant and Blakely. (1999). Medicinal Herbs in the Garden, Field, and Marketplace. Friday Flarbor, WA San Juan Naturals. Illustration by Peggy Sue McRae. [Pg.258]

Butterweck V, Wall A, Lieflander-Wulf U, Winterhoff H, Nahrstedt A. (1997). Effects of the total extract and fractions of Hypericum perforatum in animal assays for antidepressant activity. Pharmacopsychiatry. 30(suppl. 2) 117-24. [Pg.505]

Chatterjee SS, Noldner M, Koch E, Erdelmeier C. (1998b). Antidepressant activity of hypericum perforatum and hyperforin the neglected possibility. Pharmacopsychiatry. 31(suppl 1) 7-15. [Pg.506]

Cott JM. (1997). In vitro receptor binding and enzyme inhibition by Hypericum perforatum extract. Pharmacopsychiatry. 30(suppl 2) 108-12. [Pg.506]

Dimpfel W, Schober F, Mannel M. (1998). Effects of a methanolic extract and a hyperforin-enriched C02 extract of St. John s Wort (Hypericum perforatum) on intracerebral field potentials in the freely moving rat (Tele-Stereo-EEG). Pharmacopsychiatry. 31(suppl 1) 30-5. [Pg.506]

Enns MW, Cox BJ, Parker JD, Guertin JE. (1998). Confirmatory factor analysis of the Beck anxiety and depression inventories in patients with major depression. J Affective Disord. 47(1-3) 195-200. Erdelmeier CA. (1998). Hyperforin, possibly the major non-nitrogenous secondary metabolite of Hypericum perforatum L. Pharmacopsychiatry. 31(suppl 1) 2-6. [Pg.507]

Ernst E, Rand JI, Barnes J, Stevinson C. (1998). Adverse effects profile of the herbal antidepressant St. John s wort (Hypericum perforatum L.). EurJ Clin Pharmacol. 54(8) 589-94. [Pg.507]

Melzer R, Fricke U, Holzl J. (1991). Vasoactive properties of procyanidins from Hypericum perforatum L. in isolated porcine coronary arteries. Arzneimittelforschung. 41(5) 481-3. [Pg.512]

Ostrowski E. (1988). Untersuchung zur analytik, 14-Cmarkierung and pharmakokinetic phenolischer inhaltssoffe von Hypericum perforatum L. Dissertation. Marburg, FRG. P. 18 ff. [Pg.513]

Simmen U, Schweitzer C, Burkard W, Schaffner W, Lundstrom K. (1998). Hypericum perforatum inhibited the binding of mu- and kappa-opioid receptor expressed with the Semliki Forest virus system. Pharm Acta Helv. 73 53-56. [Pg.516]

Staffeldt B, Kerb R, Brockmoller J, Ploch M, Roots I. (1994). Pharmacokinetics of hypericin and pseudohypericin after oral intake of the hypericum perforatum extract LI 160 in healthy volunteers. J Geriatr Psychiatry Neurol. 7(suppl 1) S47-53. [Pg.516]

Several natural products have been evaluated in rodent models of nicotine withdrawal. An extract of Hypericum perforatum (St. John s Wort, a putative antidepressant, and inhibitor of serotonin reuptake) reversed somatically expressed withdrawal behaviors and locomotor depression in spontaneous withdrawal (Catania et al. 2003). A benzoflavone compound isolated from Passiflora incarnata, interfered with the induction of physical dependence. Coadministration with chronic nicotine prevented various subsequent indicators of withdrawal syndrome in the mouse, including jumping, locomotor inactivity, immobility in the swim test and naloxone-precipitated escape jumping (Dhawan et al. 2002). [Pg.425]

Catania MA, Firenzuoli F, Crupi A, Mannucd C, Caputi AP, Calapai G (2003) Hypericum perforatum attenuates nicotine withdrawal signs in mice. Psychopharmacology 169 186-189 Cheeta S, Irvine EE, Kenny PJ, File SE (2001) The dorsal raphd nucleus is a crucial structure mediating nicotine s anxiolytic effects and the development of tolerance and withdrawal responses. Psychopharmacology 155 78-85... [Pg.428]

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