Hypericum perforatum L.

Herbals Hypericum perforatum, L-carnitine/coenzyme QIO, Ginkgo biloba Study findings have been negative. 

Hypericum perforatum L. Hypericaceae (St John s Wort) Unknown... 

Anand, R. et al.. Comparison of extraction techniques for extraction of bioactive molecules from Hypericum perforatum L. plant, J. Chromatogr. Sci., 43, 530, 2005. 

Enns MW, Cox BJ, Parker JD, Guertin JE. (1998). Confirmatory factor analysis of the Beck anxiety and depression inventories in patients with major depression. J Affective Disord. 47(1-3) 195-200. Erdelmeier CA. (1998). Hyperforin, possibly the major non-nitrogenous secondary metabolite of Hypericum perforatum L. Pharmacopsychiatry. 31(suppl 1) 2-6. 

Ernst E, Rand JI, Barnes J, Stevinson C. (1998). Adverse effects profile of the herbal antidepressant St. John s wort (Hypericum perforatum L.). EurJ Clin Pharmacol. 54(8) 589-94. 

Melzer R, Fricke U, Holzl J. (1991). Vasoactive properties of procyanidins from Hypericum perforatum L. in isolated porcine coronary arteries. Arzneimittelforschung. 41(5) 481-3. 

Nahrstedt A, Butterweck V. (1997). Biologically active and other chemical constituents of the herb of Hypericum perforatum L. Pharmacopsychiatry. 30(suppl 2) 129-34. 

Ostrowski E. (1988). Untersuchung zur analytik, 14-Cmarkierung and pharmakokinetic phenolischer inhaltssoffe von Hypericum perforatum L. Dissertation. Marburg, FRG. P. 18 ff. 

Flavonoids in the diet have been widely promoted as important antioxidant contributors. Their neuroprotective properties, because of this effect, have been demonstrated by several workers. However, they have also been demonstrated to have MAOI activity and this has been proposed as part of the explanation of the use of the common herb, St Johns Wort, Hypericum perforatum L., as an antidepressant. This dual role has now been proposed for a variety of flavonoids, such as kaempferol (22) from the leaves of Ginkgo biloba L., a widely used herbal product which has been suggested as a preventative agent against neurodegeneration. Quercetin (23), similarly, has also shown to inhibit MAO-B " and reverse the effects of induced catalepsy, which mimics the bradykinesia associated with PD. Tangeretin (24) also inhibits MAO-B and crosses the blood brain barrier in a rat model. 

Hansen, S.H. et al.. High-performance liquid chromatography on-line coupled to high-field NMR and mass spectrometry for structure elucidation of constituents of Hypericum perforatum L., Anal. Chem., 71, 5235, 1999. 

Nathan P. The experimental and clinical pharmacology of St. John s wort (hypericum perforatum L). Mol Psychiatry 1999 4 333-338. 

Barnes J, Anderson LA, Phillipson JD. St John s wort Hypericum perforatum L.) a review of its chemistry, pharmacology and clinical properties. J Pharm Pharmacol 2001 53 583-600. 

Jurgenliemk G, Nahrstedt A. Dissolution, solubility and cooperativity of phenolic compounds from Hypericum perforatum L. in aqueous systems. Pharmazie 2003 58 200-203. 

Campbell MH, May CE, Southwell I A, Tomlinson JD, Michael PW. Variation in Hypericum perforatum L. (St. John s wort) in New South Wales. Plant Protection Quart 1997 12 64—66. 

St. John s Wort Hypericum perforatum L.) A Review. Christopher Hobbs-Health World Online, 1996. 

Hypericum perforatum L. China Quercetin, quercitrin, isoquercitrin.33-53 Antipyretic, antibacterial, detoxicant effect, treat acute icteric hepatitis, lower blood pressure, dysmenorrhea, gonorrhea, skin ailments. 

Trichosanth.es kirilowii Maxim., T. uniflora Hao Hypericum perforatum L. 

St. John s wort Hypericum perforatum L Flowers of the St. John s wort plant Antidepressant... 

The commercial products of St. John s wort are derived from the dried flowering tops or aerial parts of Hypericum perforatum L. they are harvested shortly before or during the flowering period. Hypericum preparations include the dried herb (chopped or powdered), tea infusion, liquid extract, dried (hydroalcoholic) extract, oil, and tincture. 

Hypericum (as Hypericum perforatum L.) has official status (i.e., government approval in some capacity) in several countries throughout the world. In some cases, the status is based on traditional use rather than on controlled trials. Table 43.3 shows the status of hypericum. 

Pellati, F., Benvenuti, S., and Melegari, M. 2005. Chromatographic performance of a new polar poly(ethylene glycol) bonded phase for the phytochemical analysis of Hypericum perforatum L. Journal of Chromatography A, 1088 205-17. 

NMR and msss spectrometry for structure elucidation of constituents of Hypericum perforatum L. Anal. Chem. 71 5235-5241. 

Another common plant that appears to have some activity against MRSA is Hypericum perforatum L., commonly known as St. John s wort. In traditional folk medicine, oily extracts of St. John s wort are used for topical treatment of wounds, bums and myalgia [39]. The lipophilic phloroglucin-derivative hyperforin. Fig. 3, has antibacterial effects and has been shown to inhibit the growth of MRSA at a concentration of 1 (ig/ml [39]. Thus, investigating known plants based on their historical medical (ethnomedical) use is a potentially useful means of discovering new alternative antimicrobial agents. 

Figures 3 and 4. Structures of hyperforin from Hypericum perforatum L. and berberine from Berberis vulgaris...

Kleber E, Obry T, Hippeli S, Schneider W, Elstner EF. Biochemical activities of extracts from Hypericum perforatum L. Drug Res 1999 2 106-109. 

Jensen AG, Hansen SH, Nielsen EO. Adhyperforin as a contributor to the effect of Hypericum perforatum L. in biochemical models of antidepressant activity. Life Sci 2001 68 1593-1605. 

HostanskaK, Bommer S, Weber M, Krasniqi B, Sailer R. Comparison of the growth-inhibitory effect of Hypericum perforatum L. extracts, differing in the concentration of phloroglucinols and flavonoids, on leukaemia cells. J Pharm Pharmacol 2003 55 973-980. 

Roscetti G, Franzese O, Comandini A, Bonmassar E. Cytotoxic activity of Hypericum perforatum L. on K562 erythroleukemic cells differential effects between methanolic extract and hypericin. Phytother Res 2004 18 66-72. 

Ang CY, Hu L, Heinze TM, Cui Y, et al. InstahiUty of St, John s wort (Hypericum perforatum L) and degradation of hyperforin in aqueous solutions and functional beverages. J Agric Food Chem 2004 52- 6156-6164. 

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