Hypericum lithium

The natural antidepressant hypericum perforatum is reported to have only few effects on cognitive and psychomotor performance in healthy volunteers after single doses of 900 and 1800mg only one test (DSST) within a large battery was significantly affected (Timoshanko et al., 2001). The effects of single doses of lithium on healthy volunteers are small. This also holds true when the substance is given over a period of several weeks. 

Pinselic acid (293) and related compounds, isolated from Penicillium amarum, have been synthesized from 3,6-dimethoxyphthalic anhydride and the lithium derivative (291) via the ketone (292). A number of the chlorinated xanthones found in lichens have been synthesized and their structures verified, using n.m.r. The roots of Hypericum androsaemum contain several xanthones, two of which [(294) and (295)] have an oxygenation pattern not previously known... 

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