Hypericum perforatum extract

A typical chromatogram representing the separation of Hypericum perforatum extract with the HPLC-MS attributions of the components detected is shown in Fig. 2.49. The validation parameters of the method (linearity, stability, reproducibility of the injection integration and repeatability, and robustness) were acceptable, therefore, it was found suitable for routine analysis of the composaition of the extracts of Hypericum perforatum [149],... [Pg.163]

Fig. 2.49. Profile of Hypericum perforatum extract with the H LC-MS attributions of the components detected. 1 = chlorogenic acid isomer 2 = 3-0- -coumaroylquinic acid 3 = chlorogenic acid 4 = rutin 5 = hyperoside 6 = isoquercitrin 7 = 3,3, , , 7-pentahydroxyflavanone 7-0-rhamnopyranoside 8 = quercitrin 9 = quercetin 10 = 13,118 tapigenin 11 = pSeudohypericin 12 = hypericin 13 = hyperforin analogue 14 = hyperform dialogue 15 = hyperforin 16 = adhyperforin. Reprinted with permission from M. Brolis eta. [ ].

Cott JM. (1997). In vitro receptor binding and enzyme inhibition by Hypericum perforatum extract. Pharmacopsychiatry. 30(suppl 2) 108-12. [Pg.506]

Staffeldt B, Kerb R, Brockmoller J, Ploch M, Roots I. (1994). Pharmacokinetics of hypericin and pseudohypericin after oral intake of the hypericum perforatum extract LI 160 in healthy volunteers. J Geriatr Psychiatry Neurol. 7(suppl 1) S47-53. [Pg.516]

Yu, P.H. (2000) Effect of Hypericum perforatum extract on serotonin turnover in the mouse brain. Pharmacopsychiatry 33 60-65. [Pg.376]

Noeldner M, Schotz K. Rutin is essential for the antidepressant activity of Hypericum perforatum extracts in the forced swimming test. Planta Med 2002 68 577-580. [Pg.239]

Schempp CM, Winghofer B, Langheinrich M, Schopf E, Simon JC. Hypericin levels in human serum and interstitial skin blister fluids after oral single-dose and steady-state administration of Hypericum perforatum extract (St. John s wort). Skin Pharmacol Appl Skin Physiol 1999 12 299-304. [Pg.240]

Agrosi M, Mischiatti S, Harrasser PC, Savio D. Oral bioavailability of active principles from herbal products in humans. A study on Hypericum perforatum extract using the soft gelatin capsule technology. Phytomedicine 2000 7 455-462. [Pg.240]

Vitiello B. Hypericum perforatum extracts as potential antidepressants. J Pharmacy Pharmacol 1999 51 513-517. [Pg.417]

Colovic, M. Caccia, S., Liquid chromatography-tandem mass spectrometry of 13,118-biapigenin, the major biflavone in Hypericum perforatum extracts., J. Chromatogr. B Analyt. Technol. Biomed. Life. Set, 2008, 863, 74-79. [Pg.213]

Tricyclic antidepressants are the mainstay of treatment of painful polyneuropathy, but cannot be used in a substantial number of patients. St. John s Wort (Hypericum perforatum) is a herbal antidepressant which may act via mechanisms similar to tricyclics. Clinical trials have extensively reported the ability of Hypericum perforatum extracts to exert a significant antidepressant activity [224-226], Hypericins, Fig. (13) are considered to be one of the compounds contributing to the activity of the extract [227], These... [Pg.333]

Fiume, M.Z. 2001. Final report on the safety assessment of Hypericum perforatum extract and Hypericum perforatum oil. Int. J. Toxicol. 20(Suppl. 2) 31-39. [Pg.463]

Schempp, C.M., K. Muller, B. Winghofer, J. Schulte-Monting, and J.C. Simon. 2001. Single-dose and steady-state administration of Hypericum perforatum extract (St John s wort) does not influence skin sensitivity to UV radiation, visible Ught, and solar-simulated radiation. Arch. Dermatol. 137(4) 512-513.

Hyperabsolute castoreum. SeeCastoreum Hyperfloe CP 614. See Polyquatemium-6 Hypericum extract Hypericum perforatum. See Hypericum perforatum extract Hypericum perforatum extract CAS 68917-49-7 84082-80-4 EINECS/ELINCS 282-026-4... [Pg.2150]

St. John s wort extract. See Hypericum perforatum extract STO. See Sorbitan trioleate Stoddard solvent... [Pg.4219]

Elecampane (Inula helenium) Qalbanum (Ferula galbaniflua) Hypericum perforatum extract Pansy (Viola tricolor) Peach (Prunus persica) leaf... [Pg.5274]

Hypericum perforatum extract 68917-51-1 Algae extract 68917-70-4 Ouricury wax 68917-73-7... [Pg.6618]

ESI-MS in negative mode of Hypericum perforatum extracts provides typical fingerprints showing three different classes of compounds, i.e., flavonoids, hypericins, and hyperforins (Fig. 2). The abundant ions at m z 535 and 549 are due to [M-H] ions of hyperforin and adhyperforin, respectively. Deprotonated molecules ([M-H] ) of hypericin m z 503), pseudohypericin (miz 519), and... [Pg.66]

Figure 2 Typical negative ESI-MS mass spectrum of Hypericum perforatum extract. ESI-MS, electrospray ionization mass spectrometry Mi, rutin M2, hyperforin M3, pseudohypericin M4, hypericin M5, adhyperforin Me, isoquerci-trin/hyperoside. [Pg.67]

Mauri PL, Pietta PG. Analysis of Hypericum perforatum extracts by high performance hquid chromatographyXelectrospray mass spectrometry. Rapid Com-mun Mass Spectrom 2000 14 95-99. [Pg.81]

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