Pancreatic tumor cells

Marchesi F, Monti P, Leone BE, et al. Increased survival, proliferation, and migration in metastatic human pancreatic tumor cells expressing functional CXCR4. Cancer Res 2004 64 8420-8427. 

This drug blocks binding of androgens to tissue-muscle cells and prevents biological action of androgens, inclnding in pancreatic tumor cells. 

Hajri, A., Wack, S., Lehn, P., Vigneron, J.P. and Lehn, J.M. (2000) Efficient transfer of double suicide genes (herpes simplex virus-thymidine kinase and Escherichia coh-CD) into peritoneal disseminated pancreatic tumor cells by the cationic lipid BGTC. Cancer Gene Ther., 7,1393-1393. 

Ross, J.A., Maingay, J.P., Fearon, K.C., Sangster, K., and Powell, J.J., Eicosapentaenoic acid perturbs signalling via the NFkappaB transcriptional pathway in pancreatic tumor cells, Ini. J. Oncol., 23,1733, 2003. 

In 1982 Guillemin et al. 84) and Rivier et al. 85) isolated 3 peptides 43a with GRF activity (stimulation of the secretion of growth hormone) from human pancreatic tumor cells, and synthesized them by the solid-phase method ... 

Tan, M. H. and Chu, T. M. (1985). Characterization of the tumorigenic and metastatic properties of a human pancreatic tumor cell line (ASPC-1). implanted orthotopically into nude mice. Tumor Biol. 6, 89-98. 

Lee, L.T. et al.. Blockade of the epidermal growth factor receptor tyrosine kinase activity by quercetin and luteolin leads to growth inhibition and apoptosis of pancreatic tumor cells. Anticancer Res., 22, 1615,2002. 

Cordes N, Frick S, Brunner TB et al (2007) Human pancreatic tumor cells are sensitized to ionizing radiation by knockdown of caveolin-1. Oncogene 26 6851-6862 Couet J, Sargiacomo M, Lisanti MP (1997) Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities. J Biol Chem 272 30429-30438 Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420 860-867... 

Tumor cells need certain nutrients such as iron to support their fast growing rate. Transferrin is the protein that transports iron through the bloodstream. Therefore, certain types of tumor cells overexpress transferrin receptors to capture this important element Binding transferrin to MSNPs helps in achieving a selective internalization in pancreatic tumor cells (PANC-1) and pre-metastatic breast cancer cells (BT-549) [42]. Another example of the use of proteins can be found in the functionalization of MSNPs with the cell membrane receptor CD4 that binds the glycoprotein gpl20 present on the capsid of HIV. These particles could be used in HIV diagnosis or treatment [44]. 

Nishimori, I., Perini, F., Mountjoy, K.P., Sanderson, S.D., Johnson, N., Cemy, RL, Gross, M.L., Fontenot, J.D., and Hollingsworth, M.A. N-acetylgalactosamine glycosylation of MUCI tandem repeat peptides by pancreatic tumor cell extracts. Cancer Res. 54 3738-3744, 1994. 

Quercetin has been shown to inhibit the activity of two enzymes that play an important role in mammary cell growth and development, tyrosine protein kinase activity and phosphoinositide phosphorylation, and it also inhibits protein kinase C, which is vital in the regulation of cellular proliferation. Blockade of the tyrosine kinase activity of the EGR receptor leading to growth inhibition and apoptosis in pancreatic tumor cells have been reported for quercetin and luteolin. Furthermore, inhibition of tumor growth through cell cycle arrest and induction of apoptosis by quercetin are thought to be functionally related to activation of the tumor supressor protein p53. In addition, quercetin has... 

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