Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Sodium-iodide symporter

EGER targeting was also used for systemic delivery of pDNA expressing the sodium iodide symporter (NIS) gene to liver cancer cells, followed by administration of radioactive isotope iodine-131, which accumulates in the tumor by NIS-mediated uptake in radiotherapeutic doses [227]. [Pg.16]

Breast milk During lactation human mammary tissue expresses the sodium iodide symporter [260], and thus significant transfer of perchlorate into human milk is likely. The presence of micrograms per liter concentrations of perchlorate in milk collected fi om US women [233] confirms lactation as a relevant perchlorate excretion path. If lactating women are secreting perchlorate in milk, then urine-based estimates of total perchlorate exposure for these individuals are likely to be lower than actual [242]. [Pg.281]

De Groef B, Decallonne BR, Van der Geyten S, Darras VM, Bouillon R (2006) Perchlorate versus other environmental sodium/iodide symporter inhibitors potential thyroid-related health effects. Eur J Endocrinol 155 17-25... [Pg.303]

Fig. 1 Thyroid hormone synthesis in a thyroid follicular cell. NIS and TPO (organification and coupling reaction) have been marked in red dashed line as the two main targets for direct thyroid gland function disrupters. DEHALl iodotyrosine dehalogenase 1, DIT diiodotyrosine, DUOX2 dual oxidase 2, MIT monoiodotyrosine, Na/K-ATPase sodium-potassium ATPase, NIS sodium-iodide symporter, PSD pendrin, TG thyroglobulin, TPO thyroperoxidase. Reprinted from [7] with permission from Elsevier... Fig. 1 Thyroid hormone synthesis in a thyroid follicular cell. NIS and TPO (organification and coupling reaction) have been marked in red dashed line as the two main targets for direct thyroid gland function disrupters. DEHALl iodotyrosine dehalogenase 1, DIT diiodotyrosine, DUOX2 dual oxidase 2, MIT monoiodotyrosine, Na/K-ATPase sodium-potassium ATPase, NIS sodium-iodide symporter, PSD pendrin, TG thyroglobulin, TPO thyroperoxidase. Reprinted from [7] with permission from Elsevier...
Bizhanova A, Kopp P (2009) The sodium-iodide symporter NIS and pendrin in iodide homeostasis of the thyroid. Endocrinology 150 1084—1090... [Pg.430]

Dohan O, De la Vieja A, Carrasco N (2000) Molecular study of the sodium-iodide symporter (NIS) a new field in thyroidology. Trends Endocrinol Metab 11 99-105... [Pg.432]

The perchlorate ion of potassium perchlorate, KCIO4, is a competitive inhibitor of thyroidal 1 transport via the Sodium Iodide Symporter (NIS).This drug can cause fatal aplastic anemia and gastric ulcers and is now rarely used. If administered with careful supervision, in limited low doses and for only brief periods, serious toxic effects can be avoided. The compound is especially effective in treating iodine-induced hyperthyroidism, which may occur, for example, in patients treated with the antiar-rhythmic compound amiodarone. Perchlorate ion can also be used in a diagnostic test of 1 incorporation into Tg, the so-called perchlorate discharge test. [Pg.751]

Hasegawa K, Pham L, O Connor MK, Federspiel MJ, Russell SJ, Peng KW. Dual therapy of ovarian cancer using measles viruses expressing carcinoembryonic antigen and sodium iodide symporter. Clin Cancer Res 2006 6 1868-75. [Pg.745]

Vilijn, E, and Carrasco, bf. (1989). Expression of the thyroid sodium/iodide symporter in Xenoftus loevi oocytes, /. Bioi. Chem. 264,11901-119(13. [Pg.859]

Perchloric acid s corrosive properties and ability to cause tissue oxidation are mechanisms of toxicity. Perchlorate (CIOT) disrupts endocrine homeostasis by competitively inhibiting the transport of iodide (I ) into the thyroid through the sodium iodide symporter. Potential human health risks exist from chronic exposure to perchlorate via drinking water. Such risks may include hypothyroidism, goiter, and mental retardation (if exposure occurs during critical periods in neurodevelopment). [Pg.1936]

Riedel C, Levy O, Carrasco N (2001) Post-transcriptional regulation of the sodium/ iodide symporter by thyrotropin. J Biol Chem 276(24) 21458-21463... [Pg.305]

Spitzweg C, Morris JC (2002) Sodium iodide symporter (NIS) and thyroid. Hormones (Athens) l(l) 22-34... [Pg.305]

Waltz F, Pillette L, Ambroise Y (2010) Anon-radioactive iodide uptake assay for sodium iodide symporter function. Anal Biochem 396(1/91-95... [Pg.305]

Chung JK (2002) Sodium iodide symporter its role in nuclear medicine. J Nucl Med 43(9) 1188-1200... [Pg.306]

Kogai T, Sajid-Crockett S, Newmarch LS, Liu YY, Brent GA (2008) Phosphoinositide-3-kinase inhibition induces sodium/iodide symporter expression in rat thyroid cells and human papillary thyroid cancer cells. J Endocrinol 199(2) 243-252... [Pg.306]

Liu YY, Zhang X, Ringel MD, Jhiang SM (2012) Modulation of sodium iodide symporter expression and function by LY294002, Akti-1/2 and Rapamycin in thyroid cells. Endocr Relat Cancer 19(3) 291-304... [Pg.306]

CARLIN, S., AKABANI, G, ZALUTSKY, M.R., In-vitro cytotoxicity of (211)at-astatide and (131)I-iodide to glioma tumour cells expressing the sodium/iodide symporter, J. Nucl. Med. 44 (2003) 1827-1838. [Pg.267]

A. De La Vieja, O. Dohan, O. Levy, et al. Molecular analysis of the sodium/iodide symporter impact on thyroid and extrathyroid pathophysiology. Physiological Reviews 80, 1083 (2000). [Pg.779]

Uptake of Iodide. Dietary iodine reaches the circulation as iodide. Normally, its concentration in the blood is very low (0.2-0.4 ag/dL about 15-30 uM), but the thyroid actively transports the ion via a specific, membrane-bound protein termed the sodium-iodide symporter (NIS). The ratio of thyroid to plasma iodide concentration is usually between 20 and 50 and can far exceed 100 when the gland is stimulated. The NIS is inhibited by a number of ions such as thiocyanate and perchlorate (Figure 56-3). Thyrotropin (see below) stimulates the NIS, which is controlled by an autoregulatory mechanism. Thus, decreased stores of thyroid iodine enhance iodide uptake, and the administration of iodide can reverse this situation by decreasing NIS protein expression. [Pg.979]

The use of K1 serves as an important remedy to protect from radioiodine exposure under nuclear accident conditions. In principle, under normal circumstances, excess iodine decreases sodium—iodide symporter (NIS) on the thyroid cell surface, thereby inhibiting further access for iodine into the thyroid. Excess iodide administration at the appropriate time decreases thyroid radioactive iodine uptake (RAIU) by increasing the amount of nonradioactive... [Pg.180]

Cellular Iodine Transport Body Distribution of the Human Sodium Iodide Symporter... [Pg.207]

Sodium iodide symporter A symporter that transports sodium and iodide simuitaneousiy into a oeii. [Pg.208]

See other pages where Sodium-iodide symporter is mentioned: [Pg.189]    [Pg.15]    [Pg.29]    [Pg.30]    [Pg.416]    [Pg.417]    [Pg.745]    [Pg.853]    [Pg.881]    [Pg.189]    [Pg.106]    [Pg.298]    [Pg.299]    [Pg.305]    [Pg.503]    [Pg.1254]    [Pg.1265]    [Pg.36]    [Pg.29]    [Pg.29]    [Pg.171]    [Pg.207]    [Pg.207]    [Pg.207]    [Pg.208]   
See also in sourсe #XX -- [ Pg.15 ]

See also in sourсe #XX -- [ Pg.29 , Pg.180 , Pg.208 , Pg.211 , Pg.245 , Pg.250 , Pg.283 , Pg.297 , Pg.298 , Pg.304 , Pg.307 , Pg.343 , Pg.452 , Pg.540 , Pg.702 , Pg.803 , Pg.879 , Pg.937 , Pg.992 , Pg.993 , Pg.1002 ]



SEARCH



Endogenous sodium iodide symporter

Endogenous sodium iodide symporter expression

Gastric sodium iodide symporter

Human sodium iodide symporter

Human sodium iodide symporter body distribution

Human sodium iodide symporter distribution

Sodium iodide

Sodium iodide symporter regulation

Sodium—iodide symporter/solute carrier

Symport

Symporter

Symports

© 2024 chempedia.info