Genomic functional

Dihydroxyvitamin (283) is the endogenous ligand for the vitamin receptor (VDR). It modulates genomic function in a tissue and developmentaHy specific manner and affects ceU proliferation, differentiation, and mineral homeostasis (74). Vitamin mobilizes calcium from the bone to maintain plasma Ca " levels. Vitamin and VDR are present in the CNS where they may play a role in regulating Ca " homeostasis. Vitamin D has potent immunomodulatory activity in vivo. 

Misteli T (2004) Spatial positioning a new dimension in genome function. Cell 119(2) 153-156... 

Histones are master-piece of DNA compaction, able to form a highly ordered and condensed nucleoproteic complex termed chromatin. Thereby, they play a major role in genomic function regulations. They are the target of multiple post-translational... 

The importance of DNA methylation for normal genome function can also be shown by the finding that homozygous mutation of the DNMT gene results in embryonic lethality [46]. Thus, unwanted activation of certain genes by DNMT inhibitors may pose a risk, for example by derepression of proinvasive genes [47], which puts a caveat to those therapeutical approaches. 

The genome of an organism provides a blue print for its structural and functional attributes. Genome functions through the synthesis, regulation, and activity of proteins. A dynamic and well balanced network of DNA-protein, RNA-protein, and protein-protein interactions (PPIs) maintain the cellular system as a complex but cohesive unit (1). Proteomics serves as a medium to unravel protein functions and ultimately to understand a living system or a disease condition (2-5). Over the years, classical genetic... 

DNA replication in large genomes function of the human homologue of the MCM gene family... 

Genomics, functional genomics and proteomics, with their enabfing technologies (biological and biochemical methods, instrumentation, automation techniques and databases), are revolutionizing research in biology and pharmaceutical and medical fields. 

Hirsh, A.E., and Fraser, H.B., 2003, Genomic function Rate of evolution and gene dispensability. Nature 421 497 198. 

In addition to its genomic functions, retinoic acid also has a number of nongenomic functions. It enhances the stabUity of keratin mRNA, leading to increased synthesis of this protein (Growe, 1993). Retinoic acid acts also as an effector in response to transmembrane signaling by retinoylation of target proteins. 

DEF has been reported to cause extensive alterations in morphological features of erythrocyte and nuclear membranes and affected the permeability properties of rat liver mitochondrial membrane. A reduction in the activity of cytochrome-c-oxidase and NAD. H-oxidase has also been observed. Content of both DNA and RNA decreased in tissues studied within 1 month of DEF intoxication and was usually restored within 3 months. Histological study showed development of necrodystrophy in liver tissue and of fibroplastic glomerulonephritis in kidney. The deteriorating effect of DEF on cellular genome functions... 

Willson TM, Jones SA, Moore JT, et al. Chemical genomics Functional analysis of orphan nuclear receptors in the regulation of bile acid metabolism. Med Res Rev 2001 21 513-22. 

The problems and methods introduced above have been instrumental in the advance in our understanding of genome function, organization, and... 

Data analysis in IMG is set in a multidimensional data space, whereby genes form one of the dimensions and are characterized in the context of other dimensions, in particular individual organisms (genomes), functions, and networks of... 

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