Nuclear receptors orphan

Kodama S, Negishi M (2006) Phenobarbital confers its diverse effects by activating the orphan nuclear receptor CAR. Drug Metab Rev 38 75-87... 

Orphan G protein-coupled receptors Orphan GPCRs Orphan seipentine receptors Orphan nuclear receptor... 

Giguere V Orphan nuclear receptors from gene to function. En-docr Rev 1999 20 689. 

Modulation of Xenobiotic and Other Orphan Nuclear Receptors.470... 

MODULATION OF XENOBIOTIC AND OTHER ORPHAN NUCLEAR RECEPTORS... 

Kliewer, S.A., Lehmann, J.M. and Willson, T.M. (1999) Orphan nuclear receptors shifting endocrinology into reverse. Science 284, 757-760. 

Synold, R. W., Dussault, I., Forman, B. M., The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux, Nature Med. 2001, 7, 584-590. 

Orphan Nuclear Receptor PXR-Mediated Gene Regulation in Drug Metabolism and Endobiotic Homeostasis... 

Xie, W., Uppal, H., Saini, S.P., Mu, Y., Little, J.M., Radominska-Pandya, A. and Zemaitis, M.A. (2004) Orphan nuclear receptor-mediated xenobiotic regulation in drug metabolism. Drug Discovery Today, 9, 442-449. 

A., Willson, T.M., Moore, J.T., and Kliewer, S.A. (1998) The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. Journal of Clinical Investigation, 102, 1016-1023. 

Benoit, G., Malewicz, M. and Perlmann, T. (2004) Digging deep into the pockets of orphan nuclear receptors insights from structural studies. Trends in Cell Biology, 14, 369-376. 

B., Goodwin, B., Liddle, C. Blanchard, S. G., Willson, T.M., Collins, J.L. and Kliewer, S.A (2000) Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. The Journal of Biological Chemistry, 275, 15122-15127. 

Kliewer SA, Moore JT, Wade L, Staudinger JL, Watson MA, Jones SA, McKee DD, Oliver BB, Willson TM, Zetterstrom RH, Perlmann T, Lehmann JM (1998) An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell 92 73-82... 

Preitner N, Damiola F, Lopez-Molina L et al 2002 The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell 110 251—260... 

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