Functional genomics projects

CAM-PC is a general purpose CA software simulation environment based on CAM-6, Designed by members of the GENOME Project at Eotvos University in Hungary, the first version of CAM-PC extends the possibilities of CAM-6 but is not yet fully compatible with it. The primary addition is support for 8 bit planes, increasing the size of CAM-6 s ccdl-statc alphabet to 256, The laudable purpose behind the project is to provide inexpensive but otherwise fully functional simulation tools for amateur researchers unable to afford faster dedicatcxl hardware. 

From the human genome project it is known, that roughly 30,000 proteins exist in humans. Currently only the 3D-structures of few thousand human pr oteins or protein domains are known. Structures of membrane-bound proteins are several magnitudes rarer. Beside efforts to solve further structures like structural genomics, there is a challenge for computational approaches to predict structures and function for homologous proteins. 

CYP2J2 is abundant in cardiovascular tissue and active in the metabolism of arachidonic acid to eicosanoids that possess potent anti-inflammatory, vaso-dilatory, and fibrinolytic properties. Polymorphic alleles with reduced function are known. Some other CYP2 subfamilies and isozymes listed in Table 1 are still not well characterized, in part because most of them were discovered in the course of the human genome project. 

The genome projects produce an enormous amount of sequence data that needs to be annotated in terms of molecular structure and biological function. 

One driver for new discovery will be the completion of the human genome project. As a result of this project, the locations and sequences associated with the tens of thousands of genes of the human genome will have been determined. In the post-genomic era, then, we will know the DNA sequences and genes of a human being, but that is only the start. What are the functions associated with these sequences We will need to isolate the proteins that are the gene products,... 

By the nature of its interdisciplinary nature, functional genomics is almost invariably a collaborative effort at distinct locations. A practical approach to the data management of such projects that we follow is to localize all data in one server and allow all collaborators to access it remotely, conveniently through a web browser without having to install specialized software. This also allows access by third parties, after public release of the data sets. In fact, these massive data sets cannot be published in the traditional way. One leaves the data out of journal articles and merely indicates there how to access the data directly from this system. Functional genomics is changing even the sociology of science ... 

A gene is the basic physical and functional unit of heredity. Genes, which are made up of DNA, act as instructions to make molecules called proteins. In humans, genes vary in size from a few hundred DNA bases to more than 2 million bases. The Human Genome Project has estimated that humans have between 20,000 and 25,000 genes. 

The work of the Human Genome Project has allowed researchers to begin to understand the blueprint for building a person. As researchers learn more about the functions of genes and proteins, this knowledge will have a major impact in the fields of medicine, biotechnology,... 

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