Functional genomics Genome-based proteomics

Wei, Y., and Chen, S.S. (2005) Mass spectrometry-based quantitative proteomic profiling. Briefings in functional genomics and proteomics 4, 1-12. 

Hayes, F. (2003) Transposon-based strategies for microbial functional genomics and proteomics. Annu. Rev. Genet. 37, 3-29. 

Wang, M., You, J., Bemis, K.G., Tegeler, T.J., Brown, D.P. (2008) Label-free mass spectrometry-based protein quantification technologies in proteomic analysis. Briefings in Functional Genomics and Proteomics, 7, 329-339. 

Additionally, the cellular location at which the resultant polypeptide will function often cannot be predicted from RNA detection/sequences nor can detailed information regarding how the polypeptide product s functional activity will be regulated (e.g. via post-translational mechanisms such as phosphorylation, partial proteolysis, etc.). Therefore, protein-based drug leads/targets are often more successfully identified by direct examination of the expressed protein complement of the cell, i.e. its proteome. Like the transcriptome (total cellular RNA content) and in contrast to the genome, the proteome is not static with changes in cellular... 

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