Gene and Function Prediction by Conservation of Genomic Context

Gene and Function Prediction by Conservation of Genomic Context 

In eukaryotes, conservation of the exon order of orthologous genes among species is an invaluable tool for their prediction. Exons can be predicted from genomic DNA by alignment with proteins (Gelfand et al., 1996) or with cDNAs (Florea et al., 1998), which in principle do not contain introns. However, a new, more radical approach is under development. In an alignment at the DNA level, exons can be identified 

The usage of gene order for orthology prediction is complicated by pathway duplication, the duplication of two or more genes from one pathway to produce a new pathway. In pathway duplication part of the 

Gene E. coli H. pylon B. subtilis Synechocystis B. burgdorferi T. pallidum T. maritima A. fulgidus P. horikoshii 

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III. Gene and Function Prediction by Conservation of Genomic Context. 357... 

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