Transcriptome functional genomics

Springer, A.L., Gall, A.S., Hughes, K.A., Kaisei R.J., Li, G., Lucas, D.D., Lund., K.P., Spicer, D.A., Wiley, J.P. (2002) Affinity-based immobilization tools for functional genomics. Presented at Transcriptome 2002 From Functional to Systems Biology, Seattle, WA, March 10-13, 2002. 

Integrated Functional Genomics Transcriptomics, Proteomics, and Metabolomics... 

Verjovski-Almeida, S., Feite, F.C., Dias-Neto, E., Menck, C.F. and Wilson, R.A. (2004) Schistosome transcriptome insights and perspectives for functional genomics. Trends in Parasitology 20, 304-308. 

Toghe T, Nishiyama Y, Hirai MY, Yano M, Nakajima J, Awazuhara M, Inoue E, Takahashi H, Goodenowe DB, Kitayama M, Noji M, Yamazaki M, Saito K. 2005. Functional genomics by integrated analysis of metabolome and transcriptome of Arabidopsis plants over-expressing an MYB transcription factor. Plant J42 218-235. 

Figure 1 The physiological state of the cell is measured at several levels in a functional genomic approach, all of which interact with one another to form a highly interconnected network. In particular, differences in the transcriptome, proteome, and metabolome are monitored as a means to study gene function and cellular responses to external stimuli.

Similarly, new approaches are also being applied to further unravel plant secondary metabolism at all levels, from genes to metabolites, from genome via transcriptome and proteome, to the metabolome. Besides, functional genomics, which aims at quantitatively determining the spatial and temporal accumulation of specific mRNA, proteins and metabolites is also being applied. Such an integrated... 

Consortium for the Functional Genomics of Microbial Eukaryotes. University of Manchester, U.K URL http //www. cogeme.man.ac.uk. Analysis of the transcriptome and proteome of Saccharomyces cerevisiae (yeast) and a ntunber of plant and human fungal pathogens together with a bioinformatics centre. 

In this paradigm the information encoded into the base sequence of DNA perpetuates itself through replication, and is decoded in the form of RNA molecules. Information flow continues as RNA molecules become involved in the synthesis of the proteins, the molecules that consdtute the structural and catalytic components responsible for the organism s functioning. Genome is the complete set of an organism s DNA. The transcriptome, the complete set of the RNA transcripts that are generated by a cell under specified conditions, can... 

Singh, O.V. and N. Nagaraj. 2006. Transcriptomics, proteomics and interactomics Unique approaches to track the insights of bioremediation. Brief. Functional Genom. Proteom. 4, 355-362. 

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