Functional genomics General transcription factors

Histone acetyl transferases (HATs, EC 2.3.1.48 Table 5.1) catalyse the transfer of an acetyl group to the s-amino group of lysine residues in the tails and/or cores of histones, although, as for HDACs, some HATs also modify non-his-tone substrates e.g. transcription factors). HATs generally contain multiple subunits, and the functions of the catalytic subunit depend on the presence of other subunits. Domains that cooperate to recruit the HAT to the appropriate location in the genome include bromodomains, chromodomains, WD40 repeats, Tudor domains and PHD fingers. ... 

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