Human T leukemia

Matthay, K. K., Abai, A. M., Cobb, S., Hong, K Papahadjopoulos, D., and Straubinger R. M. (1989) Role of ligand in antibody-directed endocytosis of liposomes by human T-leukemia cells. Cancer Res. 49,4879 4886. 

Rezaul, K L. Wu, V. Mayya, S.-n Wang, and D. Han. 2005. A systematic characterization of mitochondrial proteome from human T leukemia cells. Mol. Cell Proteom. 4, 169. 

Sulforaphane has been shown to induce both apoptosis and cell cycle arrest in several cell lines, including HT29 human colon cancer cells [56], LNCaP human prostate cancer cells [57], and Jurkat human T-leukemia cells [58]. Incubation of such cells with 3-30 pM SF for 24-48 hours resulted in a dose-dependent induction of apoptosis and cell cycle arrest, showing that this compound can induce apoptosis and arrest cell growth and suggesting that this activity is unlikely to be cell type specific. There is also evidence that the concentration of SF required to induce apoptosis and cell cycle arrest may be much... 

We have developed a straightforward assay (2) to evaluate the pseudopolyrotaxanes and relevant control compounds based on the ability of Gal-1 to aggregate cells, which is used to malignant advantage (27) in cancer Treatment of CEM cells (cultured human T-leukemia cells) with 10 mM... 

DiaZepin Nucleosides. Four naturally occurring dia2epin nucleosides, coformycin (58), 2 -deoxycoformycin (59), adechlorin or 2 -chloro-2 -deoxycoformycin (60), and adecypenol (61), have been isolated (1—4,174,175). The biosynthesis of (59) and (60) have been reported to proceed from adenosine and C-1 of D-ribose (30,176,177). They are strong inhibitors of adenosine deaminase and AMP deaminase (178). Compound (58) protects adenosine and formycin (12) from deamination by adenosine deaminase. Advanced hairy cell leukemia has shown rapid response to (59) with or without a-or P-interferon treatment (179—187). In addition, (59) affects interleukin-2 production, receptor expression on human T-ceUs, DNA repair synthesis, immunosuppression, natural killer cell activity, and cytokine production (188—194). 

Retroviruses Human T-cell leukemia virus (HTLV) Human T-lymphocytic tumors... 

HiBASAMi H, ACHiwA Y, FUJIKAWA T and KOMIYA T (1996) Induction of programmed cell death (apoptosis) in human lymphoid leukemia cells by catechin compounds . Anticancer Res, 16, 1943-46. 

In order to evaluate the in vitro antitumor activity of the prodrugs, compounds 20 and 21 were incubated at varied concentrations with human T-lineage acute lymphoblastic leukemia MOLT-3 cells in the presence or absence of ImM of PGA. The data from the cell proliferation assays are presented in Fig. 5.15. 

Adult T-cell leukemia Human T-cell Retrovirus RNA... 

Kalyanaraman, D. Mann, G. D. Sidhu, R. E. Stahl, S. Zolla-Prazner, J. Leibowitch, and M. Popovic, Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS), Science 220 865 (1983). 

Ueno, Y. et al. Induction of apoptosis by T-2 toxin and other natural toxins in HL-60 human promyelotic leukemia cells. Nat. Toxins. 3, 129, 1995. 

Kobe B, Center RJ, Kemp BE, Poumbouris P. 1999. Crystal structure of human T cell leukemia virus type 1 gp21 ectodomain crystallized as a maltose binding protein chimera reveals structural evolution of retroviral transmembrane proteins. Proc Natl Acad Sci USA 96 4319-4324. 

Higuchi, M., O Brien, D., Kumaravelu, P., Lenny, N., Yeoh, E.-J. and Downing, J. (2002) Expression of a conditional AMLl-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8 21) acute myeloid leukemia. Cancer Cell 1, 63-74. 

In conclusion, these results demonstrate that affinity and specificity of A2.1-restricted TCRs, selected in Tg mice by circumventing self-tolerance to universal hdm2- and wt p53-derived CTL epitopes, can be successfully delivered into human T lymphocytes. This, however, is precisely the molecular requirement to rescue the human T cell repertoire with high-affinity leukemia and tumor-reactive TCRs that have been lost due to the establishment of antigen-specific self-tolerance [13, 14]. 

J. Molldrem, S. Dermime, K. Parker, Y.Z. Jiang, D. Mavroudis, N. Hensel, P. Fukushima, and A.J. Barrett, Targeted T-cell therapy for human leukemia c 4otoxic T lymphoc34es specific for a peptide derived from proteinase 3 preferentially lyse human myeloid leukemia cells, Blood88, 2450-2457 (1996). 

Holbert, M.A., Sikorski, T., Carten, J., Snowfiack, D., Hodawadekar, S. and Marmorstein, R. (2007) The human monocytic leukemia zinc finger histone acetyltransferase domain contains DNA-binding activity implicated in chromatin targeting. The Journal of Biological Chemistry, 282 (50), 36603-36613. 

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