Serratia marcescens, polysaccharides

Serratia marcescens polysaccharide has been reported to be active against a number of other tumors, such as Sarcoma 180 (Ref. 22), Ehrlich carcinoma,22 Guerin carcinoma,23 Sarcoma M-l (Ref. 23), and Walker carcinosarcoma.24 Navashin and coworkers25 found that... 

The earliest antitumor-polysaccharide known was isolated in 194 from Serratia marcescens and became known as Shear s polysaccharide (Shear et al. 26)). Later on, a whole steries of polysaccharides of bacterial origin was tested and it became... 

It was shown that polyglucose splfate could reverse the inhibition, by polymyxin or ribonuclease, of the tumor-damaging effect of endotoxins from Serratia marcescens.m It was also demonstrated that polyglucose sulfate abolishes the ability of lysozyme to lower the fever-producing activity of the bacterial polysaccharide from the same organism. 

The yields and Mn value of the resulting chitin-chitosan hybrid polysaccharides 8 under various reaction conditions were summarized in Table 2. The yields of 8 were around 60-75% and there were little significant differences in catalysis between these two enzymes except for the reaction time. However, A4 value of 8 reached 1600 and 2020 with using chitinases from Bacillus sp. and Serratia marcescens, respectively, which correspond to 8-10 (n = 4-5) and 10-12 (n = 5-6) saccharide units, respectively. These results Indicated that values of polysaccharides are controllable to some extent by selecting enzymes from different origins. 

Preparations of pancreatic ribonuclease, ribonuclease from Actinomyces rimosus, and the nuclease from Serratia marcescens have been covalently bound to 4 3-hydroxyethylsulphonylanisole-, 4j3-hydroxyethylsulphonylaniline, and 3-Cl-2-hydroxypropyl derivatives of dextran and dialdehyde-dextran and to the 4-aminobenzyloxymethyl ester of dextran.The yield and thermal stability of the modified nucleases depends both on the amount and the character of the functional groups activating the polysaccharide. 

Repeating unit in the O-specific polysaccharide of Serratia marcescens serogroups 024, 016 and in 020. 

T. Ikekawa, Y. Ikeda, and F. Tukuoka, Antitumor activity of polysaccharides from Serratia marcescens, Gann, 66 (3), 317-318,1975. 

Bunxing, M. I., C. F. Robinow, and H. Bunxing Factors affecting the elaboration of pigment and polysaccharide by Serratia marcescens. J. Bacteriol. 58, 114 (1949). 

Creech, H. J., E. R. Breuninger, and G. A. Adams Polysaccharide-peptide complexes from Serratia marcescens cells. Can. J. Biochem. 42, 593 (1964). 

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