Aplidium albicans

Four compounds are currently under clinical investigation for their use as anticancer agents (Fimre 1). These are ecteinascidin 743 (1), from the tunicate Ecteinascidia turbinateaplidine (dehydrodidemnin B, 2) from the ascidian Aplidium albicans dolastatin 10 (3) from the sea hare Dolabella auratium and bryostatin 1 (4) from the bryozoan Bugula neritina The marine environment has also been the source of a number of anti-inflammatory compounds such as pseudopterosin E, (5). The pseudopterosins constitute the major active components in a popular line of skin care products. ... 

Dihydrodidemnin (DDB) is a depsipeptide that has been isolated from Aplidium albicans (Mediterranean tumicates). DDB was studied on Ehrlich carcinoma growing in vivo and in primary cells [112] and found to behave as a very potent inhibitor of protein synthesis. 

Aplidine, also known as dehydrodidemnin B, was isolated from a species of tunicate called Aplidium albicans and interferes with DNA and protein synthesis. Identify each amino acid residue and label it as an 1- or a d-amino acid. 

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