DNA interactive agents

Fig. 4. Structures of DNA interactive agents are given in Table 3. In structure (38) L-MeVal is 1-/V-metby1 valine.

The DNA-interactive agent oxaliplatin had a slightly different trial design leading to accelerated approval and that was used as a comparator (oxaliplatin and fluorouracil + leucovorin vs. fluorouracil + leucovorinj. The approval was on the basis of response rate but additional studies clearly demonstrated that oxaliplatin improved survival and indeed in an adjuvant setting led to a significant increase in disease-free survival (78.2% disease-free survival at 3 years vs. 72.99%, p = 0.002). ... 

Noseda A, Berens ME, White JG, Modest EJ (1988) In vitro antiproliferative activity of combinations of ether lipid analogues and DNA interactive agents against human tumor cells. Cancer Res 48 1788-1791 Obeid LM, Linardic CM, Karolak LA, Hannun YA (1993) Programmed cell death induced by ceramide. Science 259 1769-1771 O Brian CA, Vogel, VG, Singletary SE, Ward NE (1989a) Elevated protein kinase C expression in human breast tumor biopsies relative to normal breast tissue. Cancer Res 49 3215-3217... 

Luxemburgia nobilis Eichl. (leaves) Ochnaflavone (I-3, 0,II-4 —flavone-flavanone)-. 11-2,3-Dihydroochnaflavone (225). Inhibitor of DNA topoisomerases. (225) was cytotoxic to murine Ehrlich carcinoma and human leukemia K562 cells. (225) inhibited the activity of human DNA topoisomerases I and Il-a. (225) is a DNA interacting agent, which causes DNA unwinding in an assay with topoisomerase I. Likhitwitayawuid e al., 2001 [290] D Oliveira et al 2002[291],2005[59]. 

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