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Creatine

Creatine functions as a phosphagen in muscle. Neither the small amount of ATP in muscle nor the speed with which metabolic activity can be increased, and hence ADP be rephosphorylated, matches the demand for ATP for rapid or sustained muscle contraction. Muscle contains a relatively large amount [Pg.392]


Description of Method. Creatine is an organic acid found in muscle tissue that supplies energy for muscle contractions. One of its metabolic products is creatinine, which is excreted in urine. Because the concentration of creatinine in urine and serum is an important indication of renal function, rapid methods for its analysis are clinically important. In this method the rate of reaction between creatinine and picrate in an alkaline medium is used to determine the concentration of creatinine in urine. Under the conditions of the analysis, the reaction is first-order in picrate, creatinine, and hydroxide. [Pg.632]

NAPHTHALENE DERIVATIVES] (Vol 16) a-Napthol-creatine phosphate-diacetyl... [Pg.660]

Clinical Analysis. A wide range of clinically important substances can be detected and quantitated using chemiluminescence or bioluminescence methods. Coupled enzyme assay protocols permit the measurement of kinase, dehydrogenase, and oxidases or the substrates of these enzymes as exemplified by reactions of glucose, creatine phosphate, and bile acid in the following ... [Pg.275]

The loss of NADH is followed for determination of the en2yme creatine kinase. [Pg.39]

Enzymes, measured in clinical laboratories, for which kits are available include y-glutamyl transferase (GGT), alanine transferase [9000-86-6] (ALT), aldolase, a-amylase [9000-90-2] aspartate aminotransferase [9000-97-9], creatine kinase and its isoenzymes, galactose-l-phosphate uridyl transferase, Hpase, malate dehydrogenase [9001 -64-3], 5 -nucleotidase, phosphohexose isomerase, and pymvate kinase [9001-59-6]. One example is the measurement of aspartate aminotransferase, where the reaction is followed by monitoring the loss of NADH ... [Pg.40]

Detoxifica.tlon. Detoxification systems in the human body often involve reactions that utilize sulfur-containing compounds. For example, reactions in which sulfate esters of potentially toxic compounds are formed, rendering these less toxic or nontoxic, are common as are acetylation reactions involving acetyl—SCoA (45). Another important compound is. Vadenosylmethionine [29908-03-0] (SAM), the active form of methionine. SAM acts as a methylating agent, eg, in detoxification reactions such as the methylation of pyridine derivatives, and in the formation of choline (qv), creatine [60-27-5] carnitine [461-06-3] and epinephrine [329-65-7] (50). [Pg.379]

Fig. 4. Requirements, substrates, and products of Mo-nitrogenase catalysis, where I is the MoFe protein II the Fe protein and Pi is inorganic phosphate. The generating system is composed of creatine phosphate and creatine phosphokinase to recycle the inhibitory MgADP produced during catalysis to... Fig. 4. Requirements, substrates, and products of Mo-nitrogenase catalysis, where I is the MoFe protein II the Fe protein and Pi is inorganic phosphate. The generating system is composed of creatine phosphate and creatine phosphokinase to recycle the inhibitory MgADP produced during catalysis to...
A good example of an affinity label for creatine kinase has been presented (35). This enzyme catalyzes the reversible transfer of a phosphoryl group from adenosine triphosphate [56-65-5] (17) to creatine [57-00-1] (18), leading to adenosine diphosphate [7584-99-8] (19) and phosphocreatine [67-07-2]... [Pg.324]

A/-(2,3-Epoxypropyl)-A/-amidinoglycine [70363-44-9] (21) was shown to be an affinity label of creatine kinase. Its mechanism of covalent bond formation is outlined as follows ... [Pg.324]

Sodium creatine phosphate (4H2O) [922-32-7] M 327.1. See creatine phosphate di-Na salt on p. 523 in Chapter 6. [Pg.468]

Creatine (HjO) (V-guanidino-V-methylglycine) [6020-87-7] M 131.1, m 303°, pK 2.63, pKj 14.3. Likely impurities are creatinine and other guanidino compounds. Crystd from water as monohydrate. Dried under vacuum over P2O5 to give anhydrous material. [Pg.523]

Creatine phosphate di Na, 4H2O salt (phosphocreatine) [922-32-7] M 327.1, pK, 2.7, pK 4.58, pKj - 12. To 3-4g of salt in H2O (220mL) is added 4 vols of EtOH with thorough stirring and allowed to stand at 20° for 12hrs (this temp is critical as crystals did not readily form at 23° or 25°). The salt first appears as oily droplets which slowly settle and crystallise. After 12hrs the supernatant is clear. Stirring... [Pg.523]


See other pages where Creatine is mentioned: [Pg.114]    [Pg.114]    [Pg.114]    [Pg.114]    [Pg.115]    [Pg.306]    [Pg.307]    [Pg.352]    [Pg.495]    [Pg.544]    [Pg.863]    [Pg.430]    [Pg.258]    [Pg.258]    [Pg.258]    [Pg.259]    [Pg.259]    [Pg.259]    [Pg.259]    [Pg.24]    [Pg.275]    [Pg.275]    [Pg.275]    [Pg.39]    [Pg.39]    [Pg.40]    [Pg.40]    [Pg.40]    [Pg.40]    [Pg.40]    [Pg.87]    [Pg.392]    [Pg.392]    [Pg.392]    [Pg.103]    [Pg.78]    [Pg.173]    [Pg.524]   
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322 / Biochemistry creatine

ATP creatine phosphate

Adenosine triphosphate-creatine phosphotransferase

Affinity labeling creatine kinase

Amyotrophic lateral sclerosis creatine

Arginine creatine synthesis

Biomarker creatine

Blood creatine phosphokinase

Brain creatine kinase

Brain creatine metabolism

CPK (creatine phosphokinase

Cancer creatine kinase

Conformational creatine

Creatin

Creatin

Creatin kinase

Creatin phosphate

Creatin phosphokinase

Creatine 706 Tests

Creatine GAMT) deficiency

Creatine Kinase M (CKM)

Creatine adaptation

Creatine amidinohydrolase

Creatine biosynthesis

Creatine blood levels

Creatine chemical properties

Creatine chemical structure

Creatine clearance

Creatine cyclization

Creatine deficiency syndrome

Creatine dietary sources

Creatine dietary supplement

Creatine drug interactions

Creatine excretion

Creatine guanidinoacetate methyltransferase

Creatine hydrate

Creatine kinase

Creatine kinase M

Creatine kinase MB

Creatine kinase activation

Creatine kinase active site

Creatine kinase assay

Creatine kinase assay and specific activity, VIII

Creatine kinase chicken

Creatine kinase distribution

Creatine kinase drug-related effects

Creatine kinase hydrolysis

Creatine kinase in serum

Creatine kinase inhibitors

Creatine kinase isoenzymes

Creatine kinase magnesium ions

Creatine kinase monomers

Creatine kinase myocardial band

Creatine kinase other muscle enzymes

Creatine kinase rabbit muscle

Creatine kinase reaction

Creatine kinase reaction, phosphoryl

Creatine kinase serum

Creatine kinase stability, VIII

Creatine kinase structure

Creatine kinase substrate specificity

Creatine kinase temperature

Creatine kinase transition state structure

Creatine kinase, VIII

Creatine kinase, inhibition

Creatine kinase, isoforms

Creatine kinase, kinetics

Creatine kinase, serum levels

Creatine kinase-MB isoenzyme

Creatine long-term

Creatine metabolic role

Creatine metabolism

Creatine metal complexes

Creatine monohydrate

Creatine phosphate

Creatine phosphate during exercise

Creatine phosphate formation

Creatine phosphate in muscle

Creatine phosphate phosphoryl-transfer potential

Creatine phosphate reactions

Creatine phosphate shuttle

Creatine phosphate, biosynthesis

Creatine phosphate, exercise

Creatine phosphate. See

Creatine phosphokinase

Creatine phosphokinase heart

Creatine phosphokinase kinase

Creatine phosphokinase measurement

Creatine phosphorylation

Creatine physiological effects

Creatine precursors

Creatine protocols

Creatine reaction

Creatine short-term

Creatine substrate binding

Creatine supplemental

Creatine supplementation

Creatine supplements

Creatine therapy

Creatine tolerance test

Creatine transporter

Creatine, creatinine

Creatine, determination

Creatine, formation

Creatine, function

Creatine, synthesis

Creatine, taste

Creatine-kinase MM

Creatine/phosphocreatine shuttle

Duchenne muscular dystrophy, serum creatine kinase

Energy metabolism creatine

Energy metabolism creatine phosphate

Enzyme creatine kinase

Enzyme electrodes creatine

Isoenzymes of creatine kinase

Isoforms of creatine kinase

Kinases creatine kinase

Liver creatine toxicity

Malignancy creatine kinase

Markers creatine kinase

Metabolic pathways creatine

Metabolites creatine/phosphocreatine

Muscle creatine metabolism

Muscle creatine stores

Muscle enzymes creatine kinase

Muscular dystrophies creatine metabolism

Myocardial infarction creatine phosphokinase

Myopathies creatine metabolism

Phosphocreatine (creatine

Phosphoryl transfer creatine kinase

Plasma creatine

Quantification of Free ADP and Creatine Kinase Equilibrium Constant

Serum creatine

Serum creatine kinase isoenzymes

Serum creatine kinase isoforms

Skeletal muscle creatine kinase

Taurine and Creatine

Use of creatine as a dietary supplement

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