Creatine phosphate shuttle

The Creatine Phosphate Shuttle Facilitates Transport of High-Energy Phosphate From Mitochondria... 

Figure 12-14. The creatine phosphate shuttle of heart and skeletal muscle. The shuttle allows rapid transport of high-energy phosphate from the mitochondrial matrix into the cytosol. CKg, creatine kinase concerned with large requirements for ATP, eg, muscular contraction CIC, creatine kinase for maintaining equilibrium between creatine and creatine phosphate and ATP/ADP CKg, creatine kinase coupling glycolysis to creatine phosphate synthesis CK, , mitochondrial creatine kinase mediating creatine phosphate production from ATP formed in oxidative phosphorylation P, pore protein in outer mitochondrial membrane.

The scenario depicted in Figure 4.35, conversion of thecreatinc-P energy buffer, bound to myofibrils, to creatine and regeneration of creatine-P in the mitochondrion, is called the creatine phosphate shuttle. 

FIGURE 43E The creatine phosphate shuttle. Conversion of creatine phosphate bound to myofibrils to creatine, followed by regeneration of creatine phosphate in thcmitixhondria, constitutes the creatine phosphate shuttle. 

Creatine phosphate shuttle, 202 Creatinine, 202-205 Cretinism, 737 Croltn s disease, 152 Ctoss-sectional studies, 963 Ctyploxanihinc, 554 C rypts, anatomy, 117-118 Cr, -see Computed tomcigraphy CTP, see Cyridine triphosphate Curds, 424... 

FIGURE 9.2 Basic diagram of the creatine phosphate shuttle. 

Ma, T.M., D.L. Friedman, and R. Roberts, Creatine phosphate shuttle pathway in tissues with dynamic energy demand, in Creatine and Creatine Phosphate Scientific and Clinical Perspectives, M.A. Conway and J.F. Clark, Eds. Academic Press, San... 

Fig. 19.7. Some compounds with high-energy bonds. 1,3-bisphosphoglycerate and phosphoenolpyruvate are intermediates of glycolysis. Creatine phosphate is a high-energy phosphate reservoir and shuttle in brain, muscle, and spermatozoa. Acetyl CoA is a precursor of the TCA cycle. The high-energy bonds are shown in blue.

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