Metabolites creatine/phosphocreatine

The concentration of phosphocreatine is usually greater than that of ATP and that of creatine greater than that of ADP so that these metabolites diffuse more rapidly. This is because diffusion depends upon the concentrations of participants and the concentration gradient the larger the gradient, the greater is the rate of diffusion. Consequently, the shuttle is important in cells where the distance between the sites of ATP utilisation and the mitochondria is large... 

Two studies have examined the role of detection methods in the reliability of detection of brain metabolites in humans. A study has been carried out on the reproducibility of H NMR data obtained using spectroscopic imaging in the human brain. A PRESS-based pulse sequence with dual-band RF pulses was used to excite the resonances of Cho, creatine plus phosphocreatine (tCr) and NAA while simultaneously suppressing water and lipids. Spiral k-space trajectories were used for fast spectral and spatial encoding of 1 cm voxels throughout the brain. Automated quantification of the spectrum of each... 

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